MultiOrgan Multi-Parametric MRI Study

Recruiting

• Conditions: Type 2 Diabetes

• Registration Number: NCT04137705
• Lead Sponsor: Perspectum

Brief Summary

To determine the reproducibility of a single quantitative multiparametric MRI for the assessment of body composition and multiple organ structures.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-10-22
• Study First Submitted QC: 2019-10-22
• Study First Posted: 2019-10-24
• Study Start: 2019-11-04
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-24
• Last Update Posted: 2023-04-25
• Primary Completion: 2023-11-25
• Study Completion: 2023-11-25

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• Any person over 18 years of age.
• Participant is willing and able to give informed consent for participation in the investigation.
• EITHER: Participant has Type 2 Diabetes OR: Person is a healthy volunteer

Exclusion Criteria

• The participant may not enter the investigation if they have any contraindication to magnetic resonance imaging (incl. pregnancy, extensive tattoos, pacemaker, shrapnel injury, severe claustrophobia).
• Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the investigation, or may influence the result of the investigation, or the participant's ability to participate in the investigation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Assessment of repeatability (precision under the same conditions in the same subjects: 2 separate MRI acquisitions on the same scanner) of body composition and multiple organ metrics.	24 months	To determine the repeatability of multiparametric MRI in the assessment of body composition and multiple organ structures obtained within a single MR scanning session (liver, pancreas, aorta, heart, kidney, lungs and spleen)

Secondary Outcome Measures

Name	Time	Method
Assessment of the reproducibility (precision under different measurement conditions: same participants scanned on separate MRI scanners at both 1.5T and 3T) of multiparametric MRI for the assessment of body composition and multiple organ metrics.	24 months	To determine the reproducibility of multiparametric MRI in the assessment of body composition and multiple organ structures (liver, pancreas, aorta, heart, kidney, lungs and spleen) obtained within separate MR scanning sessions.

Trial Locations

Locations (3)

Beaver House; 🇬🇧 Oxford, United Kingdom

Oxford Centre for Magnetic Resonance; 🇬🇧 Oxford, United Kingdom

Gemini One; 🇬🇧 Oxford, United Kingdom