Covid-19-associated research on hand eczema in the health sector – Part 2

Not Applicable

• Conditions: L20-L30; Dermatitis and eczema

• Registration Number: DRKS00022958
• Lead Sponsor: Institut für interdisziplinäre dermatologische Prävention und Rehabilitation an der Universität Osnabrück (iDerm)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-10-07
• Study Completion: 2021-04-30
• Results First Posted: 2022-03-31
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

Presence of a signed declaration of consent
- Skin type I-III according to Fitzpatrick
- Willingness to participate in all study dates
- clinically healthy and untreated skin on the volar forearms, upper arms and hands
- Readiness to use no cosmetic cleansing and care products at the test sites on the volar forearm and upper arm 24 hours before participation in the study and during the study
- Willingness to refrain from using hair removal treatments (depilation, epilation) at the test sites on the volar forearm and upper arm from 1 week prior to the study start and during the study phase
- Willingness to not expose the test sites on the volar forearm and upper arm to intensive UV radiation (sunbathing / solarium) 6 weeks before the start of the study and during the study phase

Exclusion Criteria

- Erlanger Atopy score > 8
- known allergy to fragrances or oatmeal
- body modification (tattoos, piercings, transdermals, scarification, etc.) in the test areas
- excessive hair in test areas
- application of so-called self-tanning preparations in test areas
- taking immunosuppressive medication (e.g. cortisone)
- application of medical, anti-inflammatory preparations (e.g. cortisone cream) in the test areas in the last 7 days before the practical study phase
- pregnancy or lactation

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Increased attention regarding the effects of increased hand washing duration and frequency on epidermal barrier function and induction of inflammatory processes in the epidermis. <br><br>Recording of the duration of hand washing (study section I) is carried out at the following points in time for the parameters listed below: <br>T0 (zero survey)<br>T1 (15 minutes after skin cleansing)<br>T2 (60 minutes after skin cleansing)<br>parameter: <br>TEWL, RHF, a* value, pH <br><br>The frequency of skin cleansing (study section II) is recorded at the following points in time: <br>T0 (zero survey)<br>T1 (15 minutes after last wash)<br>T2 (60 minutes after last wash)<br>T3 (24 hours after last wash<br><br>Parameter T0-T3:<br>TEWL, RHF, a* value, pH (test field 1-8) <br><br>Only at T3:<br>Tape stripping (D-Squame®) for the determination of Natural Moisturizing Factor (NMF) and cytokines (IL-1a & IL-1aRA) additionally NMF determination by confocal Raman spectroscopy (NMF scan). <br><br>

Secondary Outcome Measures

Name	Time	Method
Development of scientifically based recommendations regarding the optimization of skin protection and skin care.