跳至主要内容
临床试验/NCT06904079
NCT06904079招募中不适用

Prediction and Intervention Effect of Rehabilitation Status for Severe Mental Disorder Patients Based on Multimodal Analysis and AI Agents

Shanghai Mental Health Center1 个研究点 分布在 1 个国家目标入组 82 人开始时间: 2024年3月12日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
82
试验地点
1
主要终点
BPRS reduction rate

研究概览

简要总结

Mental health issues represent a major public health and social problem that significantly impacts economic and social development. Compared to other diseases, mental disorders can impair various aspects of a patient' s life, including psychological, social, occupational, and educational functions, affecting their quality of life and daily living abilities. Particularly, severe mental disorders tend to have a chronic course, often resulting in diminished social functions and social withdrawal, making it difficult for patients to integrate into society. Repeated, systematic, and comprehensive rehabilitation training for patients with severe mental disorders can effectively control or delay disease recurrence, improve social functions, enhance quality of life, and facilitate patients' reintegration into society.

In recent years, the scope of mental disorder rehabilitation has expanded to include enhancing patients' social functions and promoting their integration into society. Vocational rehabilitation and social skills training are widely used in the rehabilitation treatment of patients with severe mental disorders, and some physical intervention methods, such as neurofeedback training, have also proven to be significantly effective in the rehabilitation process. However, traditional rehabilitation techniques often lack specificity and fail to meet individualized needs of patients. Additionally, the rehabilitation process lacks long-term monitoring, making it challenging to continuously assess and adjust patients' rehabilitation outcomes. Furthermore, the assessment of rehabilitation effectiveness mainly relies on patients' subjective feelings and clinical observations, lacking high-quality evidence. Therefore, there is an urgent need to introduce new rehabilitation technologies and scientifically evaluate their effectiveness to address the shortcomings of traditional methods and provide more personalized, precise, and effective rehabilitation support.

With the rise of digital health technologies, the field of mental health rehabilitation has encountered new opportunities. Compared to traditional therapies, digital health is revolutionizing the healthcare industry, moving away from traditional approaches to healthcare management to real-time personalized monitoring and therapeutic care.Technologies such as remote monitoring, virtual reality, and computer-assisted cognitive correction therapy are increasingly applied in rehabilitation. However, these methods still need improvements in data management and integration capabilities. A large amount of data accumulates in systems, recording only the training process and real-time effects of patients, without further evaluating their rehabilitation status, leading to resource waste. Therefore, there is an urgent need to develop a digital rehabilitation model that better meets the genuine needs of patients with severe mental disorders.

This study aims to integrate multimodal technology, reinforcement learning, and agent-based modeling (ABM) into the research of mental health rehabilitation to more accurately assess and predict the rehabilitation status of mental disorder patients and to more effectively guide and support decision-making in mental rehabilitation treatment.

详细描述

This study aims to integrate multimodal technology, reinforcement learning(RL), and agent-based modeling (ABM) into the research of mental health rehabilitation to more accurately assess and predict the rehabilitation status of mental disorder patients and to more effectively guide and support decision-making in mental rehabilitation treatment.

This research project is divided into three main phases: theoretical and experimental phase, multimodal analysis phase, and application and optimization phase.

Firstly, we will conduct in-depth research across 20 community mental health facilities in Shanghai. This will be combined with an analysis of existing literature and studies to understand the needs of potential users, providing theoretical support and design basis for subsequent gamification interventions. This phase of user feedback, literature review, and needs assessment will offer directional guidance for the entire research.

In the second phase, based on the user needs and literature analysis results from the previous phase, we will design and implement gamification interventions, followed by a randomized controlled trial. Simultaneously, we will collect and analyze game behavior data to systematically evaluate the actual effects of the gamification interventions. This phase, focusing on intervention design and effect evaluation, is the core part of the research, and user feedback will continuously guide us in optimizing the interventions.

In the third phase, using the Multimodal and Crossmodal AI framework(MMCRAI), we will analyze multimodal data including patients' game behavior, physiological indicators, and psychological health information to better understand the key factors and dynamic changes in the rehabilitation process. This will provide training signals for the subsequent modeling and optimization phase.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Other
盲法
None

盲法说明

This randomized trial is an open trial, and the interventions involved cannot be blinded, so the trial is open to participants, observers, and outcome evaluators.

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Registered in the Shanghai Mental Health Information Management System,
  • •Diagnosed patients with one of the six severe mental disorders: schizophrenia, schizoaffective disorder, paranoid psychosis, bipolar (affective) disorder, mental disorder due to epilepsy, and mental retardation accompanied by mental disorder,
  • •Aged between 18 and 65 years old, ④ Normal vision or hearing, or within the normal range after correction, ⑤ Patients or their families have provided informed consent for this study and signed the informed consent form.

排除标准

  • •Patients with severe physical illnesses or organic brain diseases.

研究组 & 干预措施

Intervention Group (Gamified Digital Rehabilitation)

Experimental

Participants in this arm will receive routine pharmacological treatment and standard community rehabilitation services, combined with a structured, story-based gamified digital rehabilitation intervention. The interventions are digital functional games five times a week (30 minutes each) for 3 months.

干预措施: Gamified Digital Rehabilitation (Other)

Intervention Group (Gamified Digital Rehabilitation)

Experimental

Participants in this arm will receive routine pharmacological treatment and standard community rehabilitation services, combined with a structured, story-based gamified digital rehabilitation intervention. The interventions are digital functional games five times a week (30 minutes each) for 3 months.

干预措施: Routine Care (Behavioral)

Control Group (Routine Care)

Active Comparator

Participants in this arm will receive routine pharmacological treatment and standard community rehabilitation services during the same period.

干预措施: Routine Care (Behavioral)

结局指标

主要结局

BPRS reduction rate

时间窗: Baseline (pre-intervention), immediately post-intervention (3 months), 1-month follow-up (4 months), 3-month follow-up (6 months) and 6-month follow-up (9 months).

The Brief Psychiatric Rating Scale (BPRS) was used to measure the presence and severity of psychiatric symptoms entailing positive symptoms, general psychopathology, and affective symptoms (e.g., thought disturbance, emotional withdrawal, hostility, and suspiciousness) for patients with mental illness, particularly schizophrenia. Each of the 18 items are designed to represent a discrete symptom area. Items are rated on a 7-point Likert scale, from 1 = 'not present' to 7 = 'extremely severe', with scores ranging from 18 to 126 (achieved through summing the item scores). Higher scores indicated more severity of psychiatric symptoms. Reduction rate was calculated using the following formula: reduction rate= (Score before treatment-Score after treatment)/(Score before treatment-18) × 100%. A reduction rate of BPRS score \> 25% was considered as a clinically meaningful improvement.

次要结局

  • MMAS-8(Baseline (pre-intervention), immediately post-intervention (3 months), 1-month follow-up (4 months), 3-month follow-up (6 months) and 6-month follow-up (9 months).)
  • GAD-7(Baseline (pre-intervention), immediately post-intervention (3 months), 1-month follow-up (4 months), 3-month follow-up (6 months) and 6-month follow-up (9 months).)
  • PHQ-9(Baseline (pre-intervention), immediately post-intervention (3 months), 1-month follow-up (4 months), 3-month follow-up (6 months) and 6-month follow-up (9 months).)
  • WHOQOL-BREF(Baseline (pre-intervention), immediately post-intervention (3 months), 1-month follow-up (4 months), 3-month follow-up (6 months) and 6-month follow-up (9 months).)
  • SDSS(Baseline (pre-intervention), immediately post-intervention (3 months), 1-month follow-up (4 months), 3-month follow-up (6 months) and 6-month follow-up (9 months).)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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