Sulfadoxine-pyrimethamine combinations study

Not Applicable

Completed

• Conditions: ncomplicated malaria; Infections and Infestations; Malaria

• Registration Number: ISRCTN22075368
• Lead Sponsor: niversity of Liverpool (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-07-22
• Last Update Posted: 28 November 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 450

Inclusion Criteria

1. Age more than or equal to 12 and less than 60 months, either sex
2. Weight more than or equal to 6 kg
3. Pure (on microscopic grounds) P. falciparum parasitaemia of 2000 to 200,000 ul
4. Written consent has been obtained from the parent or legal guardian

Exclusion Criteria

1. Severe malaria
2. Antimalarials in previous week
3. Other comcomitant infection at time of presentation
4. Allergy to sulphonamides
5. Involvement in the study in the previous 12 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. World Health Organization (WHO) treatment response endpoints on days 14, 28 and 42<br>2. Selection of Dihydrofolate Reductase (DHFR) and Dihydropteroate Synthetase (DHPS) resistance associated genotypes<br>3. Fever clearance time<br>4. Parasite clearance time<br>5. Change in haemoglobin between day zero to 14<br>6. Gametocyte prevalence on day seven or 14<br>7. Adverse events clinical and laboratory

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures