PALbociclib CoLlaborative Adjuvant Study
- Conditions
- Breast Cancer
- Interventions
- Drug: Standard Adjuvant Endocrine Therapy
- Registration Number
- NCT02513394
- Lead Sponsor
- Alliance Foundation Trials, LLC.
- Brief Summary
This is a prospective, two arm, international, multicenter, randomized, open-label Phase III study evaluating the addition of 2 years of palbociclib to standard adjuvant endocrine therapy for patients with HR+ / HER2- early breast cancer (EBC).
The purpose of the PALLAS study is to determine whether the addition of palbociclib to adjuvant endocrine therapy will improve outcomes over endocrine therapy alone for HR+/HER2- early breast cancer. Assessment of a variety of correlative analysis, including evaluation of the effect of palbociclib in genomically defined tumor subgroups, is planned.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 5796
- Signed informed consent prior to study specific procedures.
- Age ≥18 years (or per national guidelines).
- Pre- and postmenopausal women or men with Stage II (Stage IIA limited to max. 1000 patients) or Stage III early invasive breast cancer
- Patients with multicentric and/or multifocal and/or bilateral early invasive breast cancer are eligible if all histopathologically examined tumors meet pathologic criteria for ER+ and/or PR+ and HER2-.
- Patients must have histologically confirmed ER+ and/or PR+, HER2-, early invasive breast cancer.
- Patients must have undergone adequate (definitive) breast surgery for the current malignancy.
FFPE tumor tissue block must be confirmed to be received at the central sample repository prior to randomization.
- ECOG performance status 0-1.
- Patients must be able and willing to swallow and retain oral medication.
- Serum or urine pregnancy test must be negative in premenopausal women within 14 days of randomization, or in women with amenorrhea of less than 12 months at time of randomization.
- Patients who received neo/adjuvant therapy must be after last dose of chemotherapy and/or biologic therapy and must have sufficient resolution of side effects.
- Patients who received breast/axilla/post-mastectomy chest wall radiotherapy must be after last dose of radiotherapy and must have sufficient resolution of side effects.
- Patients must have sufficient resolution of any surgical side effects (no active wound healing complications).
-Patients must either be initiating or have already started adjuvant hormonal treatment. -
- Patients who already received neo/adjuvant endocrine therapy are eligible as long as they are enrolled within 12 months of initial histological diagnosis and after completing no more than 6 months of adjuvant endocrine therapy.
- Absolute neutrophil count ≥ 1,500/µL
- Platelets ≥ 100,000/ mm3
- Hemoglobin ≥ 10g/dL
- Total serum bilirubin ≤ ULN; or total bilirubin ≤ 3.0 × ULN with direct bilirubin within normal range in patients with documented Gilbert's Syndrome.
- Aspartate amino transferase (AST or SGOT) and alanine amino transferase (ALT or SGPT) ≤ 1.5 × institutional ULN.
- Serum creatinine below the upper limit of the institutional normal range (ULN) or creatinine clearance ≥ 60 mL/min/1.73 m2 for patients with serum creatinine levels above institutional ULN.
- Concurrent therapy with other Investigational Products.
- Prior therapy with any CDK inhibitor.
- Patients with Stage I or IV breast cancer are not eligible.
- History of allergic reactions attributed to compounds of chemical or biologic composition similar to palbociclib.
- Patients receiving any medications or substances that are potent inhibitors or inducers of
- CYP3A isoenzymes within 7 days of randomization.
- Uncontrolled intercurrent illness that would limit compliance with study requirements.
- Pregnant women, or women of childbearing potential without a negative pregnancy test within 14 days prior to randomization.
- Patients with a history of any malignancy are ineligible
- Patients who previously received endocrine therapy within 5 years prior to diagnosis of the current malignancy.
- Patients on antiretroviral therapy.
- Patients with clinically significant history of any chronic liver disease.
- Patients receiving concurrent exogenous hormone therapy (topical vaginal estrogen therapy is allowable).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm A Palbociclib Palbociclib at a dose of 125 mg orally once daily, Day 1 to Day 21 followed by 7 days off treatment in a 28-day cycle for a total duration of 2 years, in addition to standard adjuvant endocrine therapy for a duration of at least 5 years. Arm A Standard Adjuvant Endocrine Therapy Palbociclib at a dose of 125 mg orally once daily, Day 1 to Day 21 followed by 7 days off treatment in a 28-day cycle for a total duration of 2 years, in addition to standard adjuvant endocrine therapy for a duration of at least 5 years. Arm B Standard Adjuvant Endocrine Therapy Standard adjuvant endocrine therapy for a duration of at least 5 years.
- Primary Outcome Measures
Name Time Method Invasive Disease Free Survival (iDFS) 4 years Invasive disease-free survival (iDFS) for the combination of at least 5 years endocrine therapy and 2-year palbociclib treatment versus at least 5 years endocrine therapy alone in patients with histologically confirmed HR+/HER2- invasive early breast cancer (EBC) at 4 years. iDFS is defined as the time from randomization to the date of the first event: local/regional invasive ipsilateral recurrence, contralateral invasive breast cancer, distant recurrence, second primary invasive cancer of non-breast origin or death from any cause. Direct comparison between arms used time to iDFS events and Kaplan-Meier Log-rank analysis. Due to the medians not yet achieved, the percentage of patients considered iDFS at 4 years is reported.
- Secondary Outcome Measures
Name Time Method Invasive Disease Free Survival (iDFS) Excluding Second Primary Invasive Cancers of Non-breast Origin. 4 years Invasive disease-free survival (iDFS, excluding second primary invasive cancers of non-breast origin) for the combination of at least 5 years endocrine therapy and 2-year palbociclib treatment versus at least 5 years endocrine therapy alone in patients with histologically confirmed HR+/HER2- invasive early breast cancer (EBC) at 4 years. iDFS excluding second primary invasive cancers of non-breast origin is defined as the time from randomization to the date of the first event: local/regional invasive ipsilateral recurrence, contralateral invasive breast cancer, distant recurrence, or death from any cause. Second primary invasive cancers of non-breast origin will not be considered as events for this endpoint. Direct comparison between arms used time to iDFS events and Kaplan-Meier Log-rank analysis. Due to the medians not yet achieved, the percentage of patients considered iDFS at 4 years is reported.
Distant Recurrence-free Survival (DRFS) 4 years Compare time to distant recurrence-free survival (DRFS). Distant recurrence is defined according to STEEP criteria as the time from randomization to the date of the first event: distant recurrence or death from any cause. Patients with a locoregional recurrence will continue to be followed for DRFS. Surviving patients who are event-free will be censored at: the date of last disease assessment, or withdrawal of consent to be followed, or death whichever came first. Direct comparison between arms used time to DRFS events and Kaplan-Meier Log-rank analysis. Due to the medians not yet achieved, the percentage of patients considered DRFS at 4 years is reported.
Overall Survival (OS) 4 years Compare overall survival (OS). Overall survival is defined as the time period between randomization and death. Surviving patients classified as lost-to-follow up or having withdrawn consent to be followed will be censored at their date of last contact or withdrawal of consent to be followed, whichever occurs first.
Locoregional Recurrences-free Survival (LRRFS) 4 years Compare locoregional recurrence-free survival (LRRFS). LRRFS is defined as the time from randomization to the date of the first event: local/regional invasive ipsilateral recurrence, contralateral invasive breast cancer, or death from any cause. Patients with second primary invasive cancers of non-breast origin or distant recurrence will be censored at the date of diagnosis. Surviving patients who are event-free will be censored at: the date of last disease assessment, or withdrawal of consent to be followed, whichever occurs first.
Trial Locations
- Locations (434)
Hematology Oncology Associates of Central New York - East Syracuse
🇺🇸East Syracuse, New York, United States
Kaiser Permanente Sunset Medical Center
🇺🇸Los Angeles, California, United States
University of Pittsburgh Cancer Institute- Hillman Cancer Center
🇺🇸Pittsburgh, Pennsylvania, United States
Onkologisches Forschungszentrum Klinik St. Anna, Hirslanden
🇨🇭Luzern, Switzerland
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
Dana Farber Cancer Institute
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
Mercy Medical Center
🇺🇸Baltimore, Maryland, United States
University of Miami Miller School of Medicine Sylvester Cancer Center
🇺🇸Miami, Florida, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
🇺🇸Houston, Texas, United States
Houston Methodist Hospital Cancer Center
🇺🇸Houston, Texas, United States
University of California
🇺🇸San Diego, California, United States
Kaiser Permanente San Diego Medical Center
🇺🇸San Diego, California, United States
Sharp Memorial Hospital
🇺🇸San Diego, California, United States
Kaiser Permanente San Francisco Medical Center
🇺🇸San Francisco, California, United States
UCSF Helen Diller Comprehensive Cancer Center
🇺🇸San Francisco, California, United States
Kaiser Permanente San Leandro Medical Center
🇺🇸San Leandro, California, United States
Huntsman Cancer Institute - University of Utah
🇺🇸Salt Lake City, Utah, United States
Mayo Clinic in Arizona
🇺🇸Phoenix, Arizona, United States
Vanderbilt University/Ingram Cancer Center
🇺🇸Nashville, Tennessee, United States
Nashville General Hospital at Meharry
🇺🇸Nashville, Tennessee, United States
Kaiser Permanente Baldwin Park Medical Center
🇺🇸Baldwin Park, California, United States
Katmai Oncology Group
🇺🇸Anchorage, Alaska, United States
University of South Alabama Mitchell Cancer Institute
🇺🇸Mobile, Alabama, United States
Marin Cancer Center
🇺🇸Greenbrae, California, United States
Kaiser Permanente Irvine Medical Center
🇺🇸Irvine, California, United States
Kaiser Permanente Anaheim Medical Center
🇺🇸Anaheim, California, United States
Southern Cancer Center PC - Providence
🇺🇸Mobile, Alabama, United States
Kaiser Permanente Harbor City Medical Center
🇺🇸Harbor City, California, United States
Providence Alaska Cancer Center
🇺🇸Anchorage, Alaska, United States
Kaiser Permanente Bellflower Medical Center
🇺🇸Bellflower, California, United States
Marin Cancer Care
🇺🇸Greenbrae, California, United States
Long Beach Memorial Medical Center - Todd Cancer Institute
🇺🇸Long Beach, California, United States
UCSD Moores Cancer Center
🇺🇸La Jolla, California, United States
Palo Alto Medical Foundation Health Care
🇺🇸Palo Alto, California, United States
Kaiser Permanente Riverside Medical Center
🇺🇸Riverside, California, United States
Kaiser Permanente Panorama City Medical Center
🇺🇸Panorama City, California, United States
Stanford Women's Cancer Center
🇺🇸Stanford, California, United States
Kaiser Permanente Walnut Creek Medical Center
🇺🇸Walnut Creek, California, United States
Kaiser Permanente Vallejo Medical Center
🇺🇸Vallejo, California, United States
Kaiser Permanente San Marcos Medical Center
🇺🇸San Marcos, California, United States
Kaiser Permanente Santa Clara Medical Center
🇺🇸Santa Clara, California, United States
Kaiser Permanente San Jose Medical Center
🇺🇸San Jose, California, United States
Hartford Hospital
🇺🇸Hartford, Connecticut, United States
Kaiser Permanente South San Francisco Medical Center
🇺🇸South San Francisco, California, United States
Kaiser Permanente Cadillac Medical Center
🇺🇸West Los Angeles, California, United States
Memorial Sloan Cancer Center - Hartford Healthcare Center Institute at HOCC
🇺🇸New Britain, Connecticut, United States
Georgetown University Medical Center
🇺🇸Washington, District of Columbia, United States
Christiana Health System - Christiana Hospital
🇺🇸Newark, Delaware, United States
Morton Plant Hospital
🇺🇸Clearwater, Florida, United States
Memorial Health University Medical Center
🇺🇸Savannah, Georgia, United States
Mount Sinai Comprehensive Cancer Center
🇺🇸Miami Beach, Florida, United States
Illinois CancerCare-Peoria
🇺🇸Peoria, Illinois, United States
Decatur Memorial Hospital
🇺🇸Decatur, Illinois, United States
University of Illinois
🇺🇸Chicago, Illinois, United States
University of Kentucky-Markey Cancer Center
🇺🇸Lexington, Kentucky, United States
OSF Saint Anthony Medical Center
🇺🇸Rockford, Illinois, United States
McFarland Clinic PC-William R Bliss Cancer Center
🇺🇸Ames, Iowa, United States
Cancer Care Specialist of Central Illinois
🇺🇸Decatur, Illinois, United States
Greater Baltimore Medical Center
🇺🇸Baltimore, Maryland, United States
MedStar Franklin Square Medical Center Winberg Cancer Institute
🇺🇸Baltimore, Maryland, United States
Medical Oncology and Hematology Associates - Des Moines
🇺🇸Des Moines, Iowa, United States
Covenant Medical Center
🇺🇸Waterloo, Iowa, United States
Anne Arundel Medical Center
🇺🇸Annapolis, Maryland, United States
Medstar Union Memorial Hospital
🇺🇸Baltimore, Maryland, United States
JHU Sidney Kimmel Comprehensive Cancer Center LAPS
🇺🇸Baltimore, Maryland, United States
NorthShore Hematology Oncology-Libertyville
🇺🇸Skokie, Illinois, United States
Indiana University - Melvin and Bren Simon Cancer Center LAPS
🇺🇸Indianapolis, Indiana, United States
Physicians' Clinic of Iowa PC
🇺🇸Cedar Rapids, Iowa, United States
Frederick Regional Health System James M Stockman Cancer Institute
🇺🇸Baltimore, Maryland, United States
Tidal Health Peninsula Regional
🇺🇸Salisbury, Maryland, United States
MedStar Good Samaritan Hospital
🇺🇸Baltimore, Maryland, United States
Trinity Health Michigan
🇺🇸Livonia, Michigan, United States
Lowell General Hospital
🇺🇸Lowell, Massachusetts, United States
Missouri Baptist Medical Center
🇺🇸Saint Louis, Missouri, United States
Phelps Country Regional Medical Center
🇺🇸Rolla, Missouri, United States
Spectrum Health Butterworth Research Pharmacy
🇺🇸Grand Rapids, Michigan, United States
Metro Minnesota Oncology Research Consortium
🇺🇸Saint Louis Park, Minnesota, United States
Cancer Research for the Ozarks NCORP
🇺🇸Springfield, Missouri, United States
Nebraska Hematology and Oncology
🇺🇸Lincoln, Nebraska, United States
Hackensack University Medical Center
🇺🇸Hackensack, New Jersey, United States
Robert Wood Johnson University Hospital Somerset
🇺🇸Somerville, New Jersey, United States
Rutgers Cancer Center Institute of New Jersey
🇺🇸New Brunswick, New Jersey, United States
University of New Mexico Comprehensive Cancer Center
🇺🇸Albuquerque, New Mexico, United States
Montefiore Medical Center - Einstein Campus
🇺🇸Bronx, New York, United States
Carolinas Medical Center/Levine Cancer Institute
🇺🇸Charlotte, North Carolina, United States
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
Cancer Centers of Southwest Oklahoma Research
🇺🇸Lawton, Oklahoma, United States
Cleveland Clinic Cancer Center/Fairview Hospital
🇺🇸Cleveland, Ohio, United States
Penn State Milton S Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
University of Pennsylvania/Abramson Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Avera Cancer Institute-Aberdeen
🇺🇸Aberdeen, South Dakota, United States
University of Wisconsin Hospital and Clinics
🇺🇸Madison, Wisconsin, United States
Gunderson Lutheran Medical Center
🇺🇸La Crosse, Wisconsin, United States
Wheaton Franciscan Healthcare-All Saints
🇺🇸Racine, Wisconsin, United States
UW Cancer Center at ProHealth Care
🇺🇸Waukesha, Wisconsin, United States
Wheaton Franciscan Healthcare - Wauwatosa
🇺🇸Wauwatosa, Wisconsin, United States
Coffs Harbour Health Campus - MNCCI
🇦🇺Coffs Harbour, New South Wales, Australia
St Vincent's Hospital
🇦🇺Fitzroy, Victoria, Australia
Peninsula Health - Frankston Hospital
🇦🇺Melbourne, Victoria, Australia
Royal Brisbane & Women's Hospital
🇦🇺Brisbane, Queensland, Australia
Gosford Hospital
🇦🇺Gosford, New South Wales, Australia
Wollongong Hospital
🇦🇺Wollongong, New South Wales, Australia
Western Health, Sunshine Hospital
🇦🇺St. Albans, Victoria, Australia
St John of God Bunbury Hospital
🇦🇺Bunbury, Western Australia, Australia
Medical University of Graz, Gyn. Dept.
🇦🇹Graz, Austria
CHU Sart Tilman Liège (Medical Oncology)
🇧🇪Liège, Belgium
LKH Salzburg, Univ. Klinik f. Innere Med. III
🇦🇹Salzburg, Austria
Universitätsklinikum St. Pölten, Innere Medizin
🇦🇹St. Pölten, Austria
Breast Centre Dr. Wette Viktor
🇦🇹St. Veit an der Glan, Austria
Chiba Cancer Center
🇯🇵Chiba, Japan
CHC - Saint-Joseph/Oncology-Hematology
🇧🇪Liège, Belgium
Clinique et Maternite Sainte-Elisabeth - Oncology Department
🇧🇪Namur, Belgium
UZ Leuven/ Gynaecologie-Oncologie
🇧🇪Leuven, Belgium
CHU Saint Pierre/Medical Oncology
🇧🇪Brussels, Belgium
Grand Hopital de Charleroi - Oncologie-hématologie
🇧🇪Charleroi, Belgium
University Hospital Antwerp (UZA)
🇧🇪Edegem, Belgium
CHR - Centre Hospitalier Peltzer La Tourelle/ Oncology Department
🇧🇪Verviers, Belgium
GZA Ziekenhuizen (Campus Sint-Augustinus) / Oncologische Centrum
🇧🇪Wilrijk, Belgium
BC Cancer Agency- Abbotsford Centre
🇨🇦Abbotsford, British Columbia, Canada
BC Cancer Agency - Vancouver Cancer Centre
🇨🇦Vancouver, British Columbia, Canada
CHU de Québec - Hôpital du St Sacrement
🇨🇦Québec, Quebec, Canada
Allan Blair Cancer Centre
🇨🇦Regina, Saskatchewan, Canada
University Hospital Aachen
🇩🇪Aachen, Germany
Agaplesion Markus Krankenhaus
🇩🇪Frankfurt, Germany
Praxisklinik Krebsheilkunde für Frauen
🇩🇪Berlin, Germany
Onkol. GP Dres. med. Wilke/Wagner/Petzoldt
🇩🇪Fürth, Germany
Universitätsmedizin Mainz
🇩🇪Mainz, Germany
University Medical Center Hamburg-Eppendorf, Department of Gynecology
🇩🇪Hamburg, Germany
Praxis Gynäkologie Arabella
🇩🇪München, Germany
Országos Onkológiai Intézet - "B" Belgyógyászati Onkológiai és Klinikai Farmakológiai Osztály
🇭🇺Budapest, Hungary
University Clinic Oldenburg
🇩🇪Oldenburg, Germany
Oncologianova GmbH
🇩🇪Recklinghausen, Germany
Uzsoki Utcai Kórház - Onkoradiológia, Sugárterápia, Fővárosi Onkoradiológiai Központ
🇭🇺Budapest, Hungary
Petz Aladár Megyei Oktatókórház - Onkoradiológiai Osztály
🇭🇺Győr, Hungary
St. Josefs-Hospital
🇩🇪Wiesbaden, Germany
Bon Secours Hospital, Cork
🇮🇪Cork, Ireland
Department of Internal Medicine (DIMI) - IRCCS San Martino University Hospital
🇮🇹Genoa, Italy
Sheba Medical Center Tel Hashomer
🇮🇱Ramat Gan, Tel Aviv, Israel
Azienda Ospedaliero-Universitaria Careggi/Florence University/Radiation Oncology Unit
🇮🇹Florence, Italy
Hospital Vall d´Hebron
🇪🇸Barcelona, Spain
Ospedale San Raffaele
🇮🇹Milano, Italy
Nuovo Ospedale di Prato (NOP) - Azienda USL4 Prato
🇮🇹Prato, Italy
S. Anna Hospital (Ospedale Sant'Anna)- Turin
🇮🇹Turin, Italy
Nagoya City University Hospital/Dept. of Breast & Endocrine Surgery
🇯🇵Nagoya, Aichi, Japan
Department of Breast Surgery National Hospital Organization Hokkaido Cancer Center
🇯🇵Sapporo, Hokkaido, Japan
Seoul National University Hospital, Hematology-Medical Oncology
🇰🇷Seoul, Korea, Republic of
Samsung Medical Centre, Breast Cancer Center, Department of Medicine, Division of Hematology/Oncology
🇰🇷Seoul, Korea, Republic of
Máxima Medisch Centrum
🇳🇱Eindhoven, Netherlands
Zaans Medical Center
🇳🇱Zaandam, Netherlands
Zuyderland Ziekenhuis, Oncology
🇳🇱Geleen, Netherlands
Opolskie Centrum Onkologii, Oddzial Onkologii Klinicznej
🇵🇱Opole, Poland
Instytut MSF Spółka z ograniczoną odpowiedzialnością
🇵🇱Łódź, Poland
Complejo Hospitalario Universitario A Coruña (CHUAC)
🇪🇸A Coruña, Spain
Hospital Clinic Barcelona
🇪🇸Barcelona, Spain
Hospital Reina Sofía
🇪🇸Córdoba, Spain
ICO/ H. Josep Trueta
🇪🇸Girona, Spain
Hospital Universitari Sant Joan de Reus
🇪🇸Reus, Spain
Hospital Quirón Sagrado Corazón
🇪🇸Sevilla, Spain
Hospital Son Llatzer
🇪🇸Palma, Spain
Complejo Hospitalario de Navarra
🇪🇸Pamplona, Spain
Gävle Hospital, Dept. of Oncology
🇸🇪Gävle, Sweden
Sahlgrenska University Hospital, Dept. Oncology
🇸🇪Göteborg, Sweden
Hospital Universitario Virgen del Rocio
🇪🇸Sevilla, Spain
Hosital Arnau de Vilanova Valencia
🇪🇸Valencia, Spain
Spital STS AG, Onkologiezentrum Thun-Berner Oberland
🇨🇭Thun, Bern, Switzerland
IOSI-Breast Cancer Unit-Ospedale San Giovanni-Bellinzona
🇨🇭Bellinzona, Tessin, Switzerland
Kaohsiung Medical University Hospital
🇨🇳Kaohsiung, Taiwan
Universitetssjukhuset Örebro (University Hospital) Örebro, Onkologkliniken
🇸🇪Örebro, Sweden
Dep. Oncology, University Hospital
🇨🇭Basel, Switzerland
Hôpitaux Universitaires de Genève
🇨🇭Genève, Geneva, Switzerland
Kantonspital Baden
🇨🇭Baden, Aargau, Switzerland
Kantonsspital Graubünden
🇨🇭Chur, Graubünden, Switzerland
Kantonsspital St.Gallen, Onkologie/Hämatologie
🇨🇭St.Gallen, Switzerland
National Taiwan University Hospital/Department of Surgery
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital/General Surgery
🇨🇳Taipei, Taiwan
University Hospitals Bristol NHS Foundation Trust
🇬🇧Bristol, United Kingdom
Velindre Cancer Centre
🇬🇧Cardiff, United Kingdom
The Royal Marsden Sutton
🇬🇧London, United Kingdom
Charing Cross Hospital
🇬🇧London, United Kingdom
Royal Liverpool University Hospital
🇬🇧Liverpool, United Kingdom
Maidstone Hospital, Kent Oncology Centre
🇬🇧Maidstone, United Kingdom
Royal Cornwall Hospitals NHS Trust, Oncology Trials, Sunrise Centre
🇬🇧Truro, United Kingdom
City Hospital Birmingham
🇬🇧Birmingham, United Kingdom
Royal Marsden Hospital Chelsea
🇬🇧Chelsea, United Kingdom
Sunnybrook
🇨🇦Toronto, Ontario, Canada
The Jewish General Hospital
🇨🇦Montréal, Quebec, Canada
MD Anderson Cancer Center
🇪🇸Madrid, Spain
San Pedro de Alcántara
🇪🇸Cáceres, Spain
Hospital Universitario de Burgos
🇪🇸Burgos, Spain
Hospital General Universitario de Elche
🇪🇸Elche, Spain
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
CIOCC - Centro Integral Oncológico Clara Campal / Hospital HM Universitario Sanchinarro
🇪🇸Madrid, Spain
Hospital Puerta de Hierro Majadahonda, Oncologia Médica
🇪🇸Madrid, Spain
Hospital Universitario Donostia
🇪🇸San Sebastián, Spain
Hospital Clinico Universitario de Santiago
🇪🇸Santiago, Spain
Hospital Unversitario Virgen Macarena
🇪🇸Sevilla, Spain
Consorci Sanitari de Terrassa
🇪🇸Terrassa, Spain
Hospital Virgen de la Salud
🇪🇸Toledo, Spain
Hospital Clínico Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Universitario Miguel Servet
🇪🇸Zaragoza, Spain
Helios Klinikum Berlin-Buch
🇩🇪Berlin, Germany
Praxis und Tagesklinik für gynäkologische Onkologie,
🇩🇪Ebersberg, Germany
Marienhospital Bottrop, Klinik für Gynäkologie und Geburtshilfe
🇩🇪Bottrop, Germany
Albertinen Krankenhaus
🇩🇪Hamburg, Germany
St. Vincenz KH Limburg Frauenklinik
🇩🇪Limburg, Germany
Elisabeth Krankenhaus Kassel Brustzentrum
🇩🇪Kassel, Germany
HELIOS Klinik Rottweil - Gynäkologie
🇩🇪Rottweil, Germany
MVZ Eggenfelden
🇩🇪Eggenfelden, Germany
UKSH Campus Lübeck, Klinik für Frauenheilkunde und Geburtshilfe
🇩🇪Lübeck, Germany
Western States Cancer Research NCORP
🇺🇸Denver, Colorado, United States
Missouri Valley Cancer Consortium
🇺🇸Omaha, Nebraska, United States
Mayo Clinic-Rochester
🇺🇸Rochester, Minnesota, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Cancer Alliance of Nebraska
🇺🇸Omaha, Nebraska, United States
Providence Portland Medical Center
🇺🇸Portland, Oregon, United States
Wheaton Franciscan Healthcare - St. Joseph
🇺🇸Milwaukee, Wisconsin, United States
Columbia St. Mary's Water Tower Medical Commons
🇺🇸Milwaukee, Wisconsin, United States
Coborn Cancer Center at Saint Cloud Hospital
🇺🇸Saint Cloud, Minnesota, United States
Metro Minnesota Community Oncology Research Consortium
🇺🇸Saint Louis Park, Minnesota, United States
Maryland Oncology Hematology PA
🇺🇸Bethesda, Maryland, United States
University Hospital, Geelong
🇦🇺Geelong, Victoria, Australia
Macquarie University Hospital
🇦🇺Macquarie Park, New South Wales, Australia
Monument Health Rapid City Hospital
🇺🇸Rapid City, South Dakota, United States
Joliet Oncology Hematology Associates Limited
🇺🇸Joliet, Illinois, United States
NorthShore University Health System - Evanston Hospital
🇺🇸Evanston, Illinois, United States
Ingalls Memorial Hospital
🇺🇸Harvey, Illinois, United States
Juravinski Cancer Centre
🇨🇦Hamilton, Ontario, Canada
Studien GbR Braunschweig, Lorenz&HeckerWesche
🇩🇪Braunschweig, Germany
Essentia Health NCORP
🇺🇸Duluth, Minnesota, United States
Rapid City Regional Hospital/Regional Cancer Care Institute
🇺🇸Rapid City, South Dakota, United States
Städtisches Klinikum Karlsruhe
🇩🇪Karlsruhe, Germany
Studienzentrum City
🇩🇪Berlin, Germany
St. Elisabeth Krankenhaus Leipzig
🇩🇪Leipzig, Germany
Englewood Hospital and Medical Center
🇺🇸Englewood, New Jersey, United States
Kaiser Permanente Sacramento Medical Center
🇺🇸Sacramento, California, United States
Saint Joseph Mercy Hospital
🇺🇸Ann Arbor, Michigan, United States
Kaiser Permanente Roseville Medical Center
🇺🇸Roseville, California, United States
Kaiser Permanente Woodland Hills Medical Center
🇺🇸Woodland Hills, California, United States
George Washington University Medical Faculty Associates
🇺🇸Washington, District of Columbia, United States
Mayo Clinic in Florida
🇺🇸Jacksonville, Florida, United States
Emory University Hospital
🇺🇸Atlanta, Georgia, United States
Phoebe Putney Memorial Hospital
🇺🇸Albany, Georgia, United States
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
University of Chicago Cancer Center LAPS
🇺🇸Chicago, Illinois, United States
Carle Cancer Center
🇺🇸Urbana, Illinois, United States
Orchard Healthcare Research Inc.
🇺🇸Waukesha, Wisconsin, United States
McFarland Clinic, P.C.
🇺🇸Ames, Iowa, United States
IU Health Ball Memorial Hospital
🇺🇸Muncie, Indiana, United States
Iowa Oncology Research Assoc
🇺🇸Des Moines, Iowa, United States
New England Cancer Specialists - Scarborough
🇺🇸Scarborough, Maine, United States
Eastern Maine Medical Center d/b/a Northern Light Cancer Institute
🇺🇸Bangor, Maine, United States
Holy Cross Hospital
🇺🇸Silver Spring, Maryland, United States
Tufts Medical Center
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Hospital - Plymouth Jordan Club Cancer Center
🇺🇸Plymouth, Massachusetts, United States
Cancer Research Consortium of West Michigan NCORP
🇺🇸Grand Rapids, Michigan, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Mercy Hospital Saint Louis
🇺🇸Saint Louis, Missouri, United States
Southeast Nebraska Cancer Center
🇺🇸Lincoln, Nebraska, United States
New Hampshire Oncology-Hematology PA, Concord
🇺🇸Concord, New Hampshire, United States
New Hampshire Oncology-Hematology PA
🇺🇸Hooksett, New Hampshire, United States
Solinsky Center for Cancer Care
🇺🇸Hooksett, New Hampshire, United States
Dartmouth Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
Norris Cotton Cancer Center - Nashua
🇺🇸Lebanon, New Hampshire, United States
Roswell Park Cancer Institute
🇺🇸Buffalo, New York, United States
Beth Israel Medical Center - New York
🇺🇸New York, New York, United States
Northwell Health NCORP
🇺🇸New Hyde Park, New York, United States
Mary Imogene Bassett Hospital
🇺🇸Cooperstown, New York, United States
Queens Hospital Center
🇺🇸Jamaica, New York, United States
Oneonta FoxCare Center
🇺🇸Oneonta, New York, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
🇺🇸New York, New York, United States
Memorial Sloan Kettering Cancer Center - LAPS
🇺🇸New York, New York, United States
SUNY Upstate Medical University
🇺🇸Syracuse, New York, United States
The Charlotte-Mecklenburg Hospital Authority
🇺🇸Charlotte, North Carolina, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
Cone Health Cancer Center
🇺🇸Greensboro, North Carolina, United States
Kinston Medical Specialists, PA
🇺🇸Kinston, North Carolina, United States
First Health of the Carolinas - Moore Regional Hospital
🇺🇸Pinehurst, North Carolina, United States
Ohio State University Comprehensive Cancer Center
🇺🇸Columbus, Ohio, United States
Cleveland Clinic Cancer Center/Hillcrest Hospital
🇺🇸Mayfield Heights, Ohio, United States
Stephenson Cancer Center
🇺🇸Oklahoma City, Oklahoma, United States
University of Oklahoma Health Sciences Center
🇺🇸Oklahoma City, Oklahoma, United States
Hematology & Oncology Associates of Northeastern PA
🇺🇸Dunmore, Pennsylvania, United States
Lancaster General Hospital
🇺🇸Lancaster, Pennsylvania, United States
Hospital of the University of Pennsylvania Perelman Center for Advanced Medicine
🇺🇸Philadelphia, Pennsylvania, United States
Pennsylvania Hospital
🇺🇸Philadelphia, Pennsylvania, United States
UPMC MaGee Women's Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
WellSpan Health York Cancer Center
🇺🇸York, Pennsylvania, United States
Reading Hospital/McGlinn Cancer Institute
🇺🇸Wyomissing, Pennsylvania, United States
Lexington Medical Center/Lexington Oncology Associates
🇺🇸Columbia, South Carolina, United States
Avera Cancer Institute
🇺🇸Sioux Falls, South Dakota, United States
Doctors Hospital of Laredo
🇺🇸Laredo, Texas, United States
Inova Schar Cancer Institute
🇺🇸Fairfax, Virginia, United States
CAMC Cancer Center
🇺🇸Charleston, West Virginia, United States
HSHS Saint Vincent Hospital
🇺🇸Green Bay, Wisconsin, United States
ThedaCare Regional Cancer Center
🇺🇸Appleton, Wisconsin, United States
Southern Highlands Cancer Centre
🇦🇺Bowral, New South Wales, Australia
Orange Health Service
🇦🇺Orange, New South Wales, Australia
The Breast & Endocrine Centre
🇦🇺Gateshead, New South Wales, Australia
Flinders Drive
🇦🇺Bedford Park, South Australia, Australia
South West Healthcare, Warrnambool
🇦🇺Warrnambool, Victoria, Australia
Royal Hobart Hospital
🇦🇺Hobart, Tasmania, Australia
The Northern Hospital
🇦🇺Epping, Victoria, Australia
Breast Cancer Research Centre - WA
🇦🇺Nedlands, Western Australia, Australia
Peter MacCallum Cancer Centre
🇦🇺Melbourne, Victoria, Australia
LKH Univ Klinikum Graz, Dept of Internal Med. and Oncology
🇦🇹Graz, Austria
Fiona Stanley Hospital
🇦🇺Murdoch, Western Australia, Australia
LKH Feldkirch, Department of Internal Medicine
🇦🇹Feldkirch, Austria
St. Josef Krankenhaus, Department of Internal I
🇦🇹Vienna, Austria
Klinik Ottakring
🇦🇹Vienna, Austria
Salzkammergut-Klinikum Vöcklabruck
🇦🇹Voecklabruck, Austria
OLV ziekenhuis Aalst/Radiotherapy-Oncology
🇧🇪Aalst, Belgium
Landesklinikum Wr. Neustadt, Department of Surgery
🇦🇹Wr. Neustadt, Austria
Institut Jules Bordet/Medical Oncology Department
🇧🇪Brussels, Belgium
Cliniques Universitaires Saint-Luc, Oncologisch centrum
🇧🇪Bruxelles, Belgium
CancerCare Manitoba - St. Boniface Hospital
🇨🇦Winnipeg, Manitoba, Canada
Horizon Health Network - Saint John Regional Hospital
🇨🇦Saint John, New Brunswick, Canada
The Vitalite Health Network - Dr. Leon Richard
🇨🇦Moncton, New Brunswick, Canada
University Health Network Princess Margaret Cancer Centre
🇨🇦Toronto, Ontario, Canada
Kingston General Hospital, Cancer Centre of Southeastern Ontario/Oncology
🇨🇦Kingston, Ontario, Canada
Niagara Health System
🇨🇦St. Catharines, Ontario, Canada
Grand River Regional Cancer Center
🇨🇦Kitchener, Ontario, Canada
CHUM Hôtel Dieu
🇨🇦Montréal, Quebec, Canada
Frauenklinik/University Hospital Erlangen
🇩🇪Erlangen, Germany
Centrum für Hämatologie und Onkologie Bethanien
🇩🇪Frankfurt, Germany
Klinikum Frankfurt Höchst
🇩🇪Frankfurt, Germany
Universitätsfrauenklinik Halle (Saale)
🇩🇪Halle (Saale), Germany
University of Debrecen Medical Center, Clinic of Oncology
🇭🇺Debrecen, Hungary
St James's Hospital, Cancer Clinical Trials Office, Old Admin Building,
🇮🇪Dublin, Ireland
Mater Misericordiae University Hospital
🇮🇪Dublin, Ireland
St Vincent Hospital - Medical Oncology Research Department
🇮🇪Dublin, Ireland
Sligo University Hospital
🇮🇪Sligo, Ireland
Cork University Hospital, Oncology Clinical Trials Unit
🇮🇪Cork, Ireland
Szegedi Tudomanyegyetem Általános Orvostudományi Kar Szent-Györgyi Albert Klinikai Központ, Onkoterápiás Klinika
🇭🇺Szeged, Hungary
Rabin Medical Center (RMC)
🇮🇱Petah Tikva, Central, Israel
P.O. Misericordia AUSL Toscana Sud Est
🇮🇹Grosseto, Italy
Sourasky Medical Center
🇮🇱Tel-Aviv, Israel
Azienda Ospedaliero-Universitaria di Ferrara
🇮🇹Ferrara, Italy
Policlinico di Monza - Istituto di Oncologia del Policlinico di Monza
🇮🇹Monza, Italy
Ospedale "Mater Salutis" di Legnago, Dept. of Medical Oncology
🇮🇹Legnago, Italy
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.) IRCCS
🇮🇹Meldola, Italy
Istituto Europeo di Oncologia
🇮🇹Milano, Italy
Medical Oncology Unit; University Hospital of Parma (Azienda Ospedaliero-Universitaria di Parma)
🇮🇹Parma, Italy
ASST Bergamo Ovest
🇮🇹Treviglio, Italy
Severance Hospital Medical Doctor at Department of Medical Oncology
🇰🇷Seoul, Korea, Republic of
Kyoto University Hospital/Breast Surgery
🇯🇵Kyoto, Japan
National Hospital Organization Osaka National Hospital
🇯🇵Osaka, Japan
Osaka International Cancer Institute
🇯🇵Osaka, Japan
Centro Médico Zambrano Hellion
🇲🇽Monterrey, Nuevo León, Mexico
Hagaziekenhuis
🇳🇱Den Haag, Netherlands
St Antonius Hospital
🇳🇱Nieuwegein, Netherlands
Isala, Dept of Medical Oncology
🇳🇱Zwolle, Netherlands
Klinika Nowotworów Piersi i Chirurgii Rekonstrukcyjnej, Centrum Onkologii-Instytut im. Marii Skłodowskiej-Curie
🇵🇱Warsaw, Poland
Hospital da Luz
🇵🇹Lisboa, Portugal
CUF Descobertas Hospital, Hemato-Oncologia
🇵🇹Lisboa, Portugal
Centro Clinico Champalimaud
🇵🇹Lisbon, Portugal
Instituto Português de Oncologia (IPO) Francisco Gentil do Porto
🇵🇹Porto, Portugal
ICO Badalona
🇪🇸Badalona, Spain
Centro Oncologico de Galicia
🇪🇸A Coruña, Spain
Hospital General Universitario Alicante
🇪🇸Alicante, Spain
Hospital Universitari Quirón Dexeus
🇪🇸Barcelona, Spain
Hospital General de Granollers
🇪🇸Barcelona, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Consorcio Hospitalario Provincial de Castellon
🇪🇸Castellón De La Plana, Spain
Complejo asistencial universitario de Leon
🇪🇸León, Spain
Hospital Universitario Gregorio Marañón
🇪🇸Madrid, Spain
Hospital La Paz, Servicio de Oncologia Médica
🇪🇸Madrid, Spain
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
Fundación Jiménez Díaz
🇪🇸Madrid, Spain
Hospital General Universitario José Mª Morales Meseguer
🇪🇸Murcia, Spain
Hospital Universitario Fundacion Alcorcón
🇪🇸Madrid, Spain
Hospital Clínico Universitario Virgen de la Arrixaca
🇪🇸Murcia, Spain
Hospital Universitario Central de Asturias
🇪🇸Oviedo, Spain
Hospital Clínico Universitario Virgen de la Victoria
🇪🇸Málaga, Spain
Hospitali Universitari son Espases
🇪🇸Palma, Spain
Hospital de Sant Juan Despi Moisés Broggi
🇪🇸Sant Joan Despì, Spain
Hospital Clinico Universitario Lozano Blesa
🇪🇸Zaragoza, Spain
Karolinska Universitetssjukhuset, Bröstcentrum A2:00
🇸🇪Stockholm, Sweden
Akademiska Sjukhuset Uppsala (University Hospital), Onkologkliniken
🇸🇪Uppsala, Sweden
Fondazione Oncologia Lago Maggiore, Locarno
🇨🇭Locarno, Tessin, Switzerland
Luzerner Kantonsspital, Dept. of Medical Oncology
🇨🇭Luzern, Switzerland
The Beatson West of Scotland Cancer Centre
🇬🇧Glasgow, United Kingdom
University Hospitals of Leicester
🇬🇧Leicester, United Kingdom
Northern Centre for Cancer Care
🇬🇧Newcastle upon Tyne, United Kingdom
The Christie NHS Foundation Trust
🇬🇧Manchester, United Kingdom
Nottingham University Hospitals NHS TRUST UK
🇬🇧Nottingham, United Kingdom
Weston Park Hospital, Sheffield Teaching Hospitals
🇬🇧Sheffield, United Kingdom
Advent Health Orlando
🇺🇸Orlando, Florida, United States
Orlando Health Cancer Institute
🇺🇸Orlando, Florida, United States
Norton Cancer Institute - Brownsboro
🇺🇸Louisville, Kentucky, United States
Women & Infants Hospital of Rhode Island
🇺🇸Providence, Rhode Island, United States
Fox Chase Cancer Center
🇺🇸Philadelphia, Pennsylvania, United States
University Hospital Innsbruck, Department of Obstetrics and Gynaecology
🇦🇹Innsbruck, Austria
BHS Ried, Abt. f. Gynäkologie
🇦🇹Ried, Austria
Phyrn-Eisenwurzen Klinikum Steyr
🇦🇹Steyr, Austria
LKH Wolfsberg, Department of Surgery
🇦🇹Wolfsberg, Austria
Centro Oncológico Estatal ISSEMYM
🇲🇽Toluca de Lerdo, Toluca, Mexico
BC Cancer Agency - Sindi Ahluwalia Hawkins Centre for the Southern Interior
🇨🇦Kelowna, British Columbia, Canada
Brustordination Dr. Thiel
🇦🇹Weiz, Austria
Cedars Sinai Medical Center
🇺🇸Los Angeles, California, United States
BKH Kufstein, Innere Medizin
🇦🇹Kufstein, Austria
LKH Hochsteiermark Leoben
🇦🇹Leoben, Austria
Kepler Universitätsklinikum Med. Campus III
🇦🇹Linz, Austria
University Hospital Limerick, Midwestern Cancer Centre
🇮🇪Limerick, Ireland
Advocate Lutheran General Hospital
🇺🇸Park Ridge, Illinois, United States
Hospital of the Sisters of Charity Linz, Surg. Dept., Breast Health Center
🇦🇹Linz, Austria
Medical University of Vienna Department of Obstetrics and Gynaecology
🇦🇹Vienna, Austria
Medical University Vienna - Coop Group Surgery/Oncology
🇦🇹Vienna, Austria
Hospital Hietzing, Gynecology
🇦🇹Vienna, Austria
Instituto Português de Oncologia (IPO) de Lisboa Francisco Gentil
🇵🇹Lisboa, Portugal
National Cheng Kung University Hospital, Division of Hemato-Oncology, Dept. Internal Medicine
🇨🇳Tainan, Taiwan
Weinviertelklinikum Mistelbach, Department of Surgery
🇦🇹Mistelbach, Austria
Klinikum Wels - Grieskirchen GmbH, Department of Internal Medicine IV
🇦🇹Wels, Austria
Beaumont Hospital - Cancer Clinical Trials Unit
🇮🇪Dublin, Ireland
University Hospital Waterford, Cancer Research Department
🇮🇪Waterford, Ireland
National Cancer Institute Mexico, Breast Cancer Department
🇲🇽Mexico City, Mexico
HFR Fribourg, Oncology Department
🇨🇭Fribourg, Switzerland
Saskatoon Cancer Center, University of Saskatchewan
🇨🇦Saskatoon, Saskatchewan, Canada
Changhua Christian Hospital/General Surgery
🇨🇳Changhua, Changhua County, Taiwan
Brust-Zentrum Zürich
🇨🇭Zurich, Switzerland
Universitätsspital Zürich, Klinik für Onkologie
🇨🇭Zurich, Switzerland
Uniwersyteckie Centrum Kliniczne (UCK), Klinika Onkologii I Radioterapii
🇵🇱Gdansk, Poland
St. Luke's Hospital
🇺🇸Kansas City, Missouri, United States
Ochsner Medical Center
🇺🇸New Orleans, Louisiana, United States
VCU Massey Cancer Center
🇺🇸Richmond, Virginia, United States
Tom Baker Cancer Centre - Dept. of Oncology
🇨🇦Calgary, Alberta, Canada
Kaiser Permanente Oakland Medical Center
🇺🇸Oakland, California, United States
Kaiser Permanente Fontana Medical Center
🇺🇸Fontana, California, United States
Instituto Catalán de Oncología (ICO) de L'Hospitalet de Llobregat
🇪🇸Barcelona, Spain
Guy's and St Thomas' NHS Foundation Trust
🇬🇧London, United Kingdom
Thomas Jefferson University
🇺🇸Philadelphia, Pennsylvania, United States
Rhode Island Hospital
🇺🇸Providence, Rhode Island, United States
Queen Elizabeth II Health Sciences Centre
🇨🇦Halifax, Nova Scotia, Canada