KCT0005145
Recruiting
未知
Development of Biomarkers for Diabetic Nephropathy based on Exosome Multi-Omics Study
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Korea University Ansan Hospital
- Enrollment
- 260
- Status
- Recruiting
- Last Updated
- 5 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •? inclusion criteria (Type 2 diabetes)
- •Type 2 diabetes patients aged 40\-80
- •Patients who have been followed for more than 2 years
- •Patients whose albumin\-creatinine ratio and estimated glomerular filtration rate were measured two or more times before consent to study participation.
- •estimated glomerular filtration rate \=30 ml/min/1\.73m2
- •? Inclusion criteria (healthy adult)
- •40\-80 years healthy adult without hypertension, diabetes and chronic kidney disease
- •Subjects who have been followed for more than 2 years at the Korea University Ansan Hospital Genome Cohort (The Korean Genome and Epidemiology Study, KoGES)
- •estimated glomerular filtration rate \=60 ml/min/1\.73m2
Exclusion Criteria
- •Patients with type 1 diabetes or a history of diabetic ketoacidosis or end stage renal diseas
- •Patients diagnosed with chronic kidney disease not related to diabetes
- •Patients with uncontrolled blood pressure (systolic blood pressure \> 180 mmHg even after taking antihypertensive drugs) or patients taking 4 or more antihypertensive drugs
- •kidney transplant, single kidney, or genetic kidney disease
- •History of dialysis or acute kidney damage
- •Other severe systemic diseases or body mass index \<18\.5 kg / m2
- •History of malignancy within the last 5 years
- •Long\-term use of nephrotoxic drugs (eg, non\-steroidal anti\-inflammatory drugs, lithium) (over 3 months)
- •Use of steroids (over 3 weeks) or systemic immunosuppressants
- •Subjects deemed inappropriate for clinical studies (pregnant women, severe systemic diseases, psychiatric patients, etc.)
Outcomes
Primary Outcomes
Not specified
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