Development of Biomarkers for Diabetic Nephropathy based on Exosome Multi-Omics Study

Korea University Ansan Hospital0 个研究点目标入组 260 人开始时间: 待定最近更新: 2020年7月13日

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•? inclusion criteria (Type 2 diabetes)
•Type 2 diabetes patients aged 40-80
•Patients who have been followed for more than 2 years
•Patients whose albumin-creatinine ratio and estimated glomerular filtration rate were measured two or more times before consent to study participation.
•estimated glomerular filtration rate =30 ml/min/1.73m2
•? Inclusion criteria (healthy adult)
•40-80 years healthy adult without hypertension, diabetes and chronic kidney disease
•Subjects who have been followed for more than 2 years at the Korea University Ansan Hospital Genome Cohort (The Korean Genome and Epidemiology Study, KoGES)
•estimated glomerular filtration rate =60 ml/min/1.73m2

•Patients with type 1 diabetes or a history of diabetic ketoacidosis or end stage renal diseas
•Patients diagnosed with chronic kidney disease not related to diabetes
•Patients with uncontrolled blood pressure (systolic blood pressure > 180 mmHg even after taking antihypertensive drugs) or patients taking 4 or more antihypertensive drugs
•kidney transplant, single kidney, or genetic kidney disease
•History of dialysis or acute kidney damage
•Other severe systemic diseases or body mass index <18.5 kg / m2
•History of malignancy within the last 5 years
•Long-term use of nephrotoxic drugs (eg, non-steroidal anti-inflammatory drugs, lithium) (over 3 months)
•Use of steroids (over 3 weeks) or systemic immunosuppressants
•Subjects deemed inappropriate for clinical studies (pregnant women, severe systemic diseases, psychiatric patients, etc.)

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