Evaluation of stability, soft tissue and hard tissue changes in implants placed with and without application of hyaluronic acid gel

Replacement of missing teeth with an implant in partially or fullyedentulous sites has become a preferred and realistic alternative treatmentwithout involving adjacent teeth. Single tooth replacement with endosseousdental implant comprises the most widely used form with success rates of 90% to100% in terms of implant survival and prosthetic outcomes. Implantrehabilitation of missing tooth has been most widely opted treatment modalityfor partially/completely edentulous patients who aspire long term survival andsuccess rates of the replaced prosthesis. However, implant success is mostlydependent on the concept of “OSSEOINTEGRATION†proposed by Branemark inthe year 1969, which nearly takes 6 to 7 months to heal without anyintervention. Osseointegration refers to a direct structural and functionalconnection between ordered, living bone and the surface of a load-carryingimplant. Currently, an implant is considered as osseointegratedwhen there is no progressive relative movement between the implant and the bonewith which it has direct contact. Differentapproaches have been introduced lately to positively enhance the healing arounddental implants. One approach to enhance osseointegration of dental implants isthe coating with organic components of the extracellular matrix. Hyaluronicacid (HA) was First discovered in the vitreous humour ofthe eye in 1934 and subsequently synthesized in vitro in 1964, hyaluronic acid(or hyaluronate or hyaluronan) is a negatively charged, with high molecularweight (up to 107 Daltons) glycosaminoglycan found predominantly in theextracellular matrix. Hyaluronic acid possesses physiologicaland structural functions in the tissues, including cellular and extracellularinteractions, interactions with growth factors and regulation of the osmoticpressure and tissue lubrication, which helps in maintaining the tissuesstructural and homeostatic integrity. Hyaluronicacid has a multifunctional role in healing chronic lesions, including thosethat are observed in periodontal disease. HA-coatedsurface may possess a higher potency to enhance osteogenesis. This study is designed to  evaluate the efficacy of hyaluronic acid gelon implant stability, soft tissue and hard tissue changes when compared toconventional implant placement