Effect of Tetrabenazine on Stroop Interference in HD

Phase 4

Completed

• Conditions: Huntington Disease
• Interventions: Drug: Tetrabenazine withdrawal

• Registration Number: NCT01834911
• Lead Sponsor: New York Medical College

Brief Summary

Tetrabenazine has been shown to improve gating of abnormal visual stimuli and improve postural stability in Huntington disease (HD) patients as measured by computerized dynamic posturography testing. This study aims to elucidate whether partial dopaminergic depletion via low dose tetrabenazine has a similar effect on masking out of abnormal visual stimuli on the Stroop interference test.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-04-15
• Study First Submitted QC: 2013-04-15
• Study First Posted: 2013-04-18
• Primary Completion: 2018-01-01
• Study Completion: 2018-01-01
• Results First Submitted: 2025-04-09
• Status Verified: 2025-05
• Results First Submitted QC: 2025-05-11
• Last Update Submitted: 2025-05-11
• Results First Posted: 2025-05-28
• Last Update Posted: 2025-05-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 2

Inclusion Criteria

• Established diagnosis of Huntington disease by movement disorders expert
• Patients currently taking tetrabenazine.
• Patients should not have taken dopamine receptor blocking medication for at least three days

Exclusion Criteria

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Tetrabenazine withdrawal	Tetrabenazine withdrawal	Tetrabenazine will be withdrawn for at least 3 days in Huntington disease patients currently taking the medication.

Primary Outcome Measures

Name	Time	Method
Change in Stroop Interference Score	72 hours	Participants will have Stroop Visual Interference Scores measured while OFF tetrabenazine for at least 3 days. Two doses of 12.5 mg tetrabenazine will be subsequently administered: first dose just after the Stroop test and second dose 3 hours later. Stroop Visual Interference Scores will be measured again in the ON state, 6 hours after the initial OFF measurement.; Patients are analyzed according to Stroop test using Golden's Interference score (theoretical min -50, theoretical max about 98) calculated from \[(W × C)/(W + C)\] - CW, where C=color score (0-100), W=word score (0-100), CW=color word score (0-100). The Interference score analyzes cognitive interference during trials of reading of a list of color words which are printed in a different color. Lower or more negative scores are clinically better as they indicate less interference.

Trial Locations

Locations (1)

Terence Cardinal Cooke Health Care Center; 🇺🇸 New York, New York, United States