A Cohort Study on the Association Between Acid-suppressing Drugs in Pregnancy and Asthma in the Offspring
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- AstraZeneca
- 入组人数
- 10,116
- 试验地点
- 1
- 主要终点
- Relative risk of first asthma diagnosis associated with prenatal exposure to proton pump inhibitors
研究概览
简要总结
The purpose of this study is
- To estimate the association between prenatal exposure to proton pump inhibitors (PPIs) and the risk of asthma during childhood.
- To estimate the association between prenatal exposure to H2-receptor antagonists (H2RAs) and the risk of asthma during childhood.
详细描述
A cohort study on the association between acid-suppressing drugs in pregnancy and asthma in the offspring
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Females aged 18-45 years with at least one pregnancy between 1 January 1995 - 31 December 2010 (see study population description)
排除标准
- •Males, females below age 18 and 45 years and above (see study population description)
研究组 & 干预措施
All women exposed to PPI at any time during pregnancy
Exposure to PPI defined as presence of at least one prescription of a PPI any time between last menstrual period and delievry date
干预措施: Risk of asthma in offspring (Drug)
All women exposed to H2RA at any time during pregnancy
Exposure to H2RA defined as presence of at least one prescription of H2RA any time between last menstrual period and delivery date
干预措施: Risk of asthma in offspring (Drug)
结局指标
主要结局
Relative risk of first asthma diagnosis associated with prenatal exposure to proton pump inhibitors
时间窗: From 1 January 2005 till 31 December 2010, an expected average of 5 years.
Relative risk of first asthma diagnosis associated with prenatal exposure to histamine-2 receptor antagonists
时间窗: From 1 January 2005 till 31 December 2010, an expected average of 5 years
次要结局
未报告次要终点