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临床试验/NCT04103008
NCT04103008Unknown不适用

Effect of Residual Myocardial Ischemia on Recovery of Left Ventricular Function After Primary Percutaneous Coronary Intervention

Assiut University1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2019年11月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
100
试验地点
1
主要终点
Assessing change of left ventricular function

研究概览

简要总结

Recovery of the left ventricular function is variable from one patient to another, thus assessment of cardiac function by measuring left ventricular ejection fraction using echocardiography is the most common in the daily clinical practice. However, this technique has limitation related with its intra- and interobserver variability. A recent technique, 2D speckle tracking for assessing global longitudinal strain, has been introduced to reduce the variability and potentially has a higher accuracy. Speckle tracking is a method which uses two dimensions recording for measuring quantity of movement of myocardium in several segments.

Speckle-tracking echocardiography is a current noninvasive ultrasound imaging technique that allows for an objective and quantitative evaluation of global and regional myocardial function independently from the angle of insonation and from cardiac translational movements,

详细描述

Authors using 2D speckle tracking found that subclinical LV systolic dysfunction is common in patients with isolated severe mitral stenosis (MS) and is determined primarily by the hemodynamic variables of MS severity and reduced LV filling. BMV results in rapid recovery of LV systolic function in these patients through improvement in LV diastolic loading. These findings suggest that LV contractile properties in MS are modulated predominantly by LV diastolic filling rather than myocardial structural abnormality.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients with acute myocardial infarction eligible for PCI seen on admission and after 40 days

排除标准

  • cardiomyopathy
  • on cytostatic treatment.

结局指标

主要结局

Assessing change of left ventricular function

时间窗: baseline and after 40 days of PCI

measure ejection fraction

次要结局

  • Major adverse cardiovascular events(40 days)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Karim Mohamed Eltaher Abdelrahman Aly

Resident of Cardiology

Assiut University

研究点 (1)

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