Acute Compartment Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- the time when the blister appeared
研究概览
简要总结
Acute compartment syndrome (ACS) is defined as a clinical entity originated from trauma or other conditions, and remains challenging to diagnose and treat effectively. Threre is the controversy in diagnosing, treating ACS. It was found that there was no criterion about the ACS, and result unnecessary osteotomy. The presence of clinical assessment (5P) always means the necrosis of muscles and was the most serious or irreversible stage of ACS. Besides pressure methods, the threshold of pressure identifying ACS was also controversial.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Fracture patients with Schatzker V and VI,
- •Who were older than eighteen years.
排除标准
- •The exclusion criteria were pathologic, extra-articular proximal tibial fracture,
- •Patients who was eighteen years or younger.
- •Patients treated with other implant,
- •underwent conservative management were also excluded.
结局指标
主要结局
the time when the blister appeared
时间窗: up to 4 weeks
The relative data was collected about the time when the blister appeared after injury
No non-anatomic gap or step (larger than 5 mm)
时间窗: through study completion, an average of 1 year
The relative data was collected about complications
secondary loss of reduction
时间窗: through study completion, an average of 1 year
The relative data was collected about complications
superficial wound problems
时间窗: through study completion, an average of 1 year
The relative data was collected about complications
blister skin immunochemistry and immunofluorescence analysis
时间窗: through study completion, an average of 1 year
CK1, 5, 10, claudin 1, 2 and occludin as determined by immunochemistry analysis, and skin barrier proteins; claudin 1, 2 and occludin was determined by immunofluorescence analysis and qPCR.
injury mechanism
时间窗: up to 1 weeks
The relative data was collected about injury mechanism such as high falling accident, traffic accident, fall from standing height,Crushing
time to reconstructive surgery
时间窗: time to when the surgery was conducted after 2 weeks
The relative data was collected about time to reconstructive surgery
union time
时间窗: through study completion, an average of 1 year
The relative data was collected about union time
Deep venous thrombosis
时间窗: through study completion, an average of 1 year
The relative data was collected about complications
次要结局
- chloride levels(through hospitalization completion, an average of 1 month)
- UREA levels(through hospitalization completion, an average of 1 month)
- CK levels(through hospitalization completion, an average of 1 month)