Head Stabilization of Healthy Volunteers

Active, not recruiting

• Conditions: Healthy

• Registration Number: NCT07116759
• Lead Sponsor: Abramson Cancer Center at Penn Medicine

Brief Summary

A robotic platform will use data from motion-detection cameras to position a person's head in real time. This procedure is non-invasive and since healthy volunteers are enrolled in this study, no radiation is delivered, but in the future, we plan to use this device during radiation treatment with patients.

Detailed Description

This study aims to passively monitor the real-time head motions of healthy volunteers positioned to simulate whole brain radiation therapy. Such real-time head motion data is necessary in order to understand the type (amplitude/frequency) of motion that the robotic stage will be expected to compensate for and will play an important role in the overall modeling and designing process of the robotic prototype.

Study Timeline

• Study Start: 2022-10-09
• Primary Completion: 2024-01-12
• Status Verified: 2025-08
• Study First Submitted: 2025-08-07
• Study First Submitted QC: 2025-08-07
• Last Update Submitted: 2025-08-07
• Study First Posted: 2025-08-12
• Last Update Posted: 2025-08-12
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Subjects 18 and older
• Subjects must be able to read and understand English
• Participants must sign the informed consent form

Exclusion Criteria

Any subjects not meeting the above inclusion criteria will not be considered for this study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Collection of head motion data to be used in developing head stabilization methods in brain radiation patients	2 years	The endpoint is purely quantitative in nature and will be determined by analyzing the real-time 6D target motion during the procedure. Volunteer head motion data will be imported into Matlab research software and analyzed in terms of quantifying several basic motion parameters such as mean and maximum positional deviation, velocity of the motion, and net motion trajectory. These results will be used to quantify the performance of the head positioning stage in maintaining an accurate head position.

Trial Locations

Locations (1)

University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States