ISRCTN62185868CompletedNot Applicable
A Randomised Placebo Controlled Trial of a Cholinesterase Inhibitor in the Management of Agitation in Dementia that is Unresponsive to a Psychological Interventio
King's College London (UK)0 sites285 target enrollmentStarted: September 21, 2000Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 285
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
Inclusion Criteria
- •1. Probable or possible Alzheimer's disease (AD)
- •2. Clinically significant agitation
- •3. Age >39 years
- •4. Resident in care facility or community resident with carer
- •5. Not receiving treatment with neuroleptics or chlornesterase inhibitors
- •6. Carer with capacity to consent.
Exclusion Criteria
- •1. Known sensitivity to donepezil or resperidone
- •2. Severe, unstable or uncontrolled medical conditions apparent from history, physical examination or investigations
- •3. Current evidence of delirium
- •4. Patient meets criteria for Probable Dementia with Lewy Bodies (McKeith et al, 1996)
- •5. Low probability of treatment compliance
Investigators
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