Selegiline Transdermal System for the Treatment of Cocaine Dependence - 1
- Conditions
- Cocaine-Related Disorders
- Registration Number
- NCT00032929
- Lead Sponsor
- National Institute on Drug Abuse (NIDA)
- Brief Summary
The purpose of this study is to evaluate the Selegiline Transdermal System for the treatment of cocaine dependence.
- Detailed Description
The study objectives are to assess the efficacy and safety of the Selegiline Transdermal System (STS) in reducing cocaine use in subjects with cocaine dependence. It is hypothesized that selegiline treatment compared to placebo, will be associated with fewer days of cocaine use as assessed by self-report confirmed with urine assays for benzoylecgonine (BE).
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 269
- Male/Female
- At least 18 years of age
- DSM-4 diagnosis of cocaine dependence
- Ability to understand and provide written consent
- Female subjects must use acceptable birth control
- Additional Criteria available during the screening process at the site.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Weekly mean proportion of cocaine non-use days Measured reductions in cocaine and other drug use
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (16)
Haight-Ashbury Free Clinic
🇺🇸Berkeley, California, United States
Cincinnati VA Medical Center
🇺🇸Cincinnati, Ohio, United States
VA North Texas Health Care System
🇺🇸Dallas, Texas, United States
University of Texas Hlth Sci Ctr Houston
🇺🇸Houston, Texas, United States
Tucson VA Medical Center
🇺🇸Tucson, Arizona, United States
New Orleans VA Medical Center
🇺🇸New Orleans, Louisiana, United States
Friends Research Institute
🇺🇸Los Angeles, California, United States
VA Maryland Healthcare System
🇺🇸Baltimore, Maryland, United States
Salt Lake City VA Medical Center
🇺🇸Salt Lake City, Utah, United States
Friends Research Institute-2
🇺🇸Los Angeles, California, United States
San Francisco General Hosptial
🇺🇸San Francisco, California, United States
San Francisco VA Medical Center
🇺🇸San Francisco, California, United States
Wayne State University
🇺🇸Detroit, Michigan, United States
Denver VA Medical Center
🇺🇸Denver, Colorado, United States
VA Puget Sound Health Care System
🇺🇸Seattle, Washington, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States