COVID-19-associated alterations of brain structure and functional connectomics

Recruiting

• Conditions: Z22.8; Z20.8; Carrier of other infectious diseases; Contact with and exposure to other communicable diseases

• Registration Number: DRKS00022257
• Lead Sponsor: Klinikum der Universität München, Campus Großhadern

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-02-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

All patients (age >18 years, no restrictions regarding gender and ethnic origin) who were examined as part of the NAPKON HAP cohort (as a result of a proven (PCR test) COVID-19 disease) and underwent one or more cranial MRI scan will included in the analysis.

Exclusion Criteria

- Patients without cranial MRI examination
- Lack of proof of COVID-19 disease
- Contraindication for MR imaging (metal, renal insufficiency, lack of compliance)

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Symptom severity: fatigue<br>The study population includes all patients of the HAP cohort of NAPKON in the recovery phase of COIVD-19 that underwent a cranial MRI scan (follow-up visits after 3, 6 and 12 months). <br>All study testing will be based on a 5% significance level. As the study character is mainly exploratory, no alpha adjustment will be made for multiple testing.

Secondary Outcome Measures

Name	Time	Method
Symptom severity: depression or anxiety