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临床试验/NCT04399733
NCT04399733撤回不适用

EMPOWER - BAME vs COVID: A Multi-site Clinical Cohort Research Study to Identify Genetic Associations and Candidate Therapeutic Targets to Reduce COVID-19 Morbidity & Mortality Rates in BAME Populations

Future Genetics Limited1 个研究点 分布在 1 个国家开始时间: 2021年2月1日最近更新:
适应症

试验速览

阶段
不适用
状态
撤回
发起方
试验地点
1
主要终点
Identify COVID-19 specific host-defence ("protective") or predisposing ("susceptibility") genetic biomarkers

研究概览

简要总结

The COVID-19 virus pandemic has massively affected us all. Moreover, there is a disproportionately high number of COVID-19 severe infections and deaths in British Black, Asian and minority ethnic (BAME) patients. This clinical study plans to discover new ways of protecting people from this virus by looking at our DNA and biology.

详细描述

The COVID-19 virus pandemic has massively affected us all. We now know there is a much larger proportion of British Black, Asian and minority ethnic (BAME) patients suffering from COVID-19 infections. This disproportionate level of infection and severity of disease has raised concerns and worries. Other research from April 2020 showed that 71% of the nurses and midwives and 94% of the doctors and dentists that died of COVID-19 infections were from a BAME background despite this group representing 20% and 44% of the workforce respectively. The survival picture is also grim for Black and Asian members of the public where we see disproportionately high rates of deaths. Research estimates that our DNA and the environment equally influence the risk for infection. This clinical study plans to better understand our DNA. Some of the things we will be looking at is age, sex, ethnicity and any illnesses such as diabetes or blood pressure. We will ask people for some spit and look at their medical records. This may help us find some of the reasons why this virus has different effects on people and how we might protect people from COVID-19.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
6 Years 至 —(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All competent adult and children above the age of 5 years
  • Subjects agree to:
  • Gift saliva (spit) samples
  • Provide Consent for access to medical and health records

排除标准

  • Patient is not registered with the NHS for care.
  • Adults lacking capacity
  • Children under the age of 6 years.

结局指标

主要结局

Identify COVID-19 specific host-defence ("protective") or predisposing ("susceptibility") genetic biomarkers

时间窗: 30 months

Discovery of genetic associations with COVID-19 infections that may form the basis of prevention, treatment or management of at-risk BAME groups and the wider population.

次要结局

  • Epidemiological profiles of COVID-19 infections in different UK ethnic populations(24 months)

研究者

发起方
Future Genetics Limited
申办方类型
Other
责任方
Sponsor

研究点 (1)

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