Kidney function assessment with finger-prick blood tests in different people and different settings
Not Applicable
- Conditions
- Renal failureUrological and Genital Diseases
- Registration Number
- ISRCTN31697115
- Lead Sponsor
- King's College London
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 415
Inclusion Criteria
1. 18 years of age or older
2. Willing to complete all study procedures
3. Patients undergoing formal nuclear medicine glomerular filtration rate testing (Study A only)
4. Has Chronic Kidney disease (CKD) KDIGO criteria or is at risk of CKD due to heart disease or diabetes as determined by physician (Study B only)
Exclusion Criteria
1. Unable or unwilling to give informed consent
2. Any condition which would make finger prick contraindicated e.g. severe skin conditions, bleeding disorder
3. Study A: If formal GFR testing has been requested only because estimated GFR is not considered to reflect true GFR (e.g. liver disease)
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Measured at a single time point:<br>Study A: <br>1. Estimated glomerular filtration rate (eGFR) measured using Point of care – creatinine (POC-Cr)<br>2. Formal GFR assessment (Measured GFR (MGFR) and Venous Creatinine) measured using venous creatinine results from the laboratory and the MGFR results from the nuclear medicine department<br>Study B:<br>1. Test success rate, safety, training time, patient experience and acceptability of serial capillary POC-Cr testing measured on the final visit using SUTAQ questionnaire
- Secondary Outcome Measures
Name Time Method Study B:<br>Measured during baseline and final visit:<br>1. Capillary creatinine measured using Point of care – creatinine (POC-Cr)<br>2. Venous serum enzymatic creatinine concentrations (serum Cr) measured using venous creatinine results from the laboratory