Molecular Indicators of Systematic Fitness
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- A multi-analyte biomarker panel to predict maximal aerobic capacity
研究概览
简要总结
The goal of this study is to characterize associations between cardiorespiratory fitness, as measured by VO₂max/VO₂peak, and blood-based molecular measurements in adults. This is an observational study where research staff measures VO₂max/VO₂peak and collects fasted, resting blood samples on the same day. The main questions it aims to answer are:
- Can a multi-analyte blood panel accurately predict directly measured VO₂max/VO₂peak?
- How do these blood-based features vary across age, sex, and self-reported or documented physical activity profiles?
- Are the predictor analytes able to capture changes in VO₂max/VO₂peak caused by a self-directed intervention (e.g., training for a marathon)?
- What is the analytic reliability of the predictor biomarkers?
详细描述
Prospective observational cohort with baseline cross-sectional assessment; optional longitudinal follow-up with repeat VO₂max and blood collection in a subset. No intervention is assigned by the investigators. The investigators are amassing a large dataset of diverse individuals with directly measured VO2max paired with blood samples to support robust biomarker development.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Be ≥18 years old
- •Be able to understand and provide informed consent (English; additional languages may be added via amendment with translated materials)
- •Be willing to complete VO₂max testing, blood draw, and questionnaires.
- •Be able to safely perform maximal/symptom-limited exercise testing as determined by: PAR-Q+ screening and investigator review (included as an attachment) and resting vitals screening (heart rate)
排除标准
- •Conditions that, in the investigator's judgment, or a medical doctor, makes maximal exercise testing unsafe (e.g., unstable cardiovascular symptoms)
- •Contraindications or unwillingness to undergo venipuncture
- •Acute illness (fever, significant respiratory illness) at the time of testing
- •Failure to comply with procedures.
结局指标
主要结局
A multi-analyte biomarker panel to predict maximal aerobic capacity
时间窗: Day 1
The primary outcome is developing a multi-protein biomarker panel that can accurately estimate cardiorespiratory fitness from the blood.
The change in VO2max/VO2peak and a multi-analyte biomarker panel after a self-directed training program.
时间窗: From day 1 through study completion, average of 3 months
In a subset of individuals who opt-in for a second study visit, the investigators will analyze the change in VO2max and the multi-analyte biomarker from pre- to post-testing.
次要结局
未报告次要终点