Evaluation of a novel alternative protein source to stimulate post-exercise muscle protein synthesis

Completed

• Conditions: muscle growth; Muscle protein synthesis; 10037008; 10028302

• Registration Number: NL-OMON47452
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

* Healthy males
* Age between 18 and 35 y inclusive
* BMI between 18.5 and 30 kg/m2

Exclusion Criteria

* Use of tobacco products
* Non-steroidal anti-inflammatory drugs (NSAID) in the 4 days prior to the experimental trial
* Allergies to milk proteins (whey or casein)
* Allergies to house dust mites or crustaceans
* Lactose intolerance
* Phenylketonuria (PKU)
* Blood donation within 2 months of study initiation
* Arthritic conditions
* A history of neuromuscular problems
* Previous participation in amino acid tracer studies
* Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications)
* Diabetes
* Training more than 5 days per week

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>From p23 of C1 protocol document:<br /><br><br /><br>The main study endpoint is the fractional synthetic rate (FSR) of muscle<br /><br>protein synthesis (myofibrillar proteins) from 0-5 hours in the post-prandial<br /><br>period.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>From p23 of C1 protocol document:<br /><br><br /><br>* The fractional synthetic rate (FSR) of muscle protein synthesis (myofibrillar<br /><br>proteins) from -3-0, 0-2 and 2-5 hours in the postabsorptive and<br /><br>post-prandial period respectively.<br /><br>* Plasma free phenylalanine enrichment (expressed as MPE)<br /><br>* Plasma free tyrosine enrichment (expressed as MPE)<br /><br>* Plasma total phenylalanine (expressed as *mol/L)<br /><br>* Plasma total tyrosine (expressed as *mol/L)<br /><br>* Total plasma amino acids (AAmax [*mol/L])<br /><br>* Plasma glucose (glucosemax [mmol/L])<br /><br>* Plasma insulin (insulinmax [mU/L])<br /><br>* Plasma total phenylalanine, leucine and tyrosine concentrations (expressed as<br /><br>*mol/L) </p><br>