Vitality Oriented Innovation for the Lifecourse of the Ageing Society - Intervention Study

Recruiting

Conditions: veroudering (immunometabool, darmgezondheid, spiergezondheid/functioneren)
Ageing
getting older

Registration Number: NL-OMON54190

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 220

Inclusion Criteria

All participants: age 60 or older, body mass index 18.5-35.0 kg/m2,
community-dwelling, mentally competent (MMSE score 24 or over). Depending on
the group the main additional criteria are: 1) metabolically compromised group:
Metabolomic Mortality Score within the top half of the batch of subjects 60
years and older from and also outside the LLS cohort 2) mobility compromised
group: using a walking aid and/or slow 5-times chair stand test (>15 seconds)
3) total knee replacement groups (intervention group and control group): living
in/or around the areas of Maastricht, Eindhoven, and Venlo/Roermond/Nijmegen
and underwent elective total knee replacement surgery ~6 weeks before start of
study 4) healthy active reference group: meeting the Dutch norms for being
physically active, Metabolic Mortality Score below the top half of of the batch
of subjects 60 years and older from and also outside the LLS cohort

Exclusion Criteria

Already using prebiotic fibres or high doses of supplements, contraindications
for using milk/lactose/calcium/vitamin D, engagement in intense physical
activity, (aforementioned criteria are not exclusion criteria for the reference
group), eGFR <30 ml/min/1.73 m2, diseases, conditions or disorders which may
affect the ability to follow the study protocol and which cannot be overcome
with help of a caregiver, current participation in other scientific research
that conflicts with this study, Not signed up to a general practitioner, No
permission to request information from the general practitioner/ treating
specialist(s) about medical history, medication use

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study endpoints are the intervention effects on metabolic outcomes<br /><br>(glucose, glycoprotein acetyl, very low-density lipoprotein diameter), faecal<br /><br>bifidobacterial count, time for the 5-times chair stand test and appendicular<br /><br>lean mass in the intervention groups.</p><br>

Secondary Outcome Measures