Analysis of Biopsies With Antibody Mediated Rejection According to the Therapy Response
- Conditions
- Antibody-mediated Rejection
- Registration Number
- NCT03430414
- Lead Sponsor
- Thomas Mueller
- Brief Summary
In adult kidney transplant recipients a therapy-responder and non-responder phenotype by antibody mediated rejection will be precisely defined according to clinical and histological characteristics such as creatinine, proteinuria and Banff-classification. Twenty-five patients will be selected each in the therapy-responder and non-responder group. Their stored Formalin Fixed Paraffin Embedded (FFPE) biopsies will be (re)-classified according to the most recent Banff classification. Using Nanostring Technology the gene transcription of therapy-responders versus non-responders will be analyzed and compared to serological and clinical parameters.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- Kidney transplant patients at the University Hospital of Zurich between 01.01.2008 - 31.12.2016 with histologically suspected or confirmed ABMR
- Written consent for further use of data for research purposes
- Age at transplantation < 18 years
- Combined organ transplantation (incl. Kidney-Pancreas, Kidney-Liver, Kidney-Heart)
- Incomplete laboratory and/or clinical data
- Recurrence of the initial disease
- Insufficient Biopsy Material for NanoString Analysis
- Documented refusal of further data analysis for research purpose
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Transcriptome 02.15.2018-03.01.2018 mRNA
- Secondary Outcome Measures
Name Time Method