Interventions to Promote Brain Health Virtual Reality Study
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 150
- Locations
- 1
- Primary Endpoint
- MST memory performance
Overview
Brief Summary
The Interventions for Brain Health Virtual Reality Study is a NIH-funded clinical research trial at the University of California San Diego (UCSD) Health under the supervision of the study principal investigator Dr. Judy Pa. The overarching goal of this trial is to use a novel virtual reality (VR) based intervention that simultaneously engages physical and cognitive activity aimed at improving brain health and cognition in older adults. The investigators will compare 3 types of interventions: physical activity, VR cognitive activity, and combined VR physical and cognitive activity over 16 weeks to evaluate physical and brain health changes.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Factorial
- Primary Purpose
- Prevention
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 50 Years to 85 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •50-85 years of age
- •Fluent in English
- •Can safely ride a stationary bike
Exclusion Criteria
- •History of a neurological disorder
- •Severe sensory deficits
- •Inability to perform intervention (e.g., inability to cycle safely)
- •Contraindications to MRI scan (e.g., pacemaker)
- •Fear of needles/ blood
- •Prior history of fainting due to sight of needles of blood
Outcomes
Primary Outcomes
MST memory performance
Time Frame: 16 Weeks
With the study's primary focus on hippocampal function, we will use the Mnemonic Separation Task (MST), a hippocampus-dependent discrimination test of similar objects, as our primary cognitive outcome. The MST is a memory task designed to heavily tax memory processes for making fine discriminations between highly similar objects or unrelated objects.
Secondary Outcomes
No secondary outcomes reported
Investigators
Judy Pa
Co-Director of ADCS
University of California, San Diego