A two-centre randomised controlled trial investigating the effect of remote ischaemic preconditioning (RIPC) on blood and myocardial biomarkers of stress and injury-related signalling in patients having isolated coronary artery bypass grafting (CABG) or aortic valve replacement (AVR) using cardiopulmonary bypass (CPB)

Imperial College London (UK)0 sites120 target enrollmentMarch 25, 2013

Overview

Phase: N/A
Intervention: Not specified
Conditions: Not specified
Sponsor: Imperial College London (UK)
Enrollment: 120
Status: Completed
Last Updated: 7 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

2015 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/25899533 2. 2018 results in https://www.ncbi.nlm.nih.gov/pubmed/30544237

Registry

who.int

Start Date

March 25, 2013

End Date

June 30, 2015

Last Updated

7 years ago

Study Type

Interventional

Sex

All

Investigators

Sponsor

Imperial College London (UK)

Eligibility Criteria

Inclusion Criteria

•Current inclusion criteria as of 03/11/2014:
•1\. Age \=18
•2\. Patients undergoing elective (or urgent) first\-time CABG or AVR
•Previous inclusion criteria:
•1\. Male and female, age \>\=40 and \<85 years
•2\. Patients undergoing elective (or urgent) first\-time CABG or AVR

Exclusion Criteria

•Current exclusion criteria as of 03/11/2014:
•1\. Cardiogenic shock or cardiac arrest,
•2\. Significant peripheral arterial disease affecting upper limbs,
•3\. Renal failure (with a GFR \< 30 ml/min/1\.73m2\),
•4\. Glibenclamide or nicorandil (as these medications may interfere with RIPC)
•5\. Participation in another interventional study.
•6\. Neither upper limb available for the intervention
•Previous exclusion criteria:
•1\. Cardiogenic shock or cardiac arrest
•2\. Significant peripheral arterial disease affecting upper limbs

Outcomes

Primary Outcomes

Not specified

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