Effect of Atrial Pacing on Right Ventricular Function After Cardiac Surgery
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 主要终点
- right ventricular ejection fraction
研究概览
简要总结
Temporary pacing with an external pacemaker after open heart surgery - besides preventing arrhythmias and AV-conduction disorders - is used to improve cardiac output. In theory, postoperative stunning temporarily limits stroke volume and SA-node dysfunction compromises an adequate compensatory rise in heartrate to ensure sufficient cardiac output. There is a lack of consensus regarding the use of this form of pacing. Protocols vary widely between hospitals. Moreover, the scientific base for this form of pacing mainly comprises studies dating back to the nineteen sixties and seventies. Major changes in (operating) techniques have taken place since then. Also, the role of the right ventricle in this context has not been studied specifically. The current study aims to investigate the effects of atrial pacing on right ventricular function specifically and hemodynamics in general, in today's postoperative setting. We hypothesize that a reduction in heart rate may lead to decreased right ventricular function.
详细描述
When a hemodynamically stable state is achieved, the external pacemaker will be switched off for 30 minutes. Hemodynamic parameters will be acquired directly prior to switching off, 15 respectively 30 minutes after switching off, and 15 minutes after switching back on. To gain insight in the natural course of stunning, this routine will be repeated the next morning. No additional hemodynamic interventions will be allowed in these periods.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18 years or older
- •admitted to the ICU after onpump open heart surgery
- •Swan Ganz thermodilurion catheter in situ
排除标准
- •participation other trials
- •off pump cardiac surgery
结局指标
主要结局
right ventricular ejection fraction
时间窗: 30 minutes after procedure
difference in right ventricular function expressed in RVEF
次要结局
未报告次要终点
研究者
E.C. Boerma
Principal Investigator
Medical Centre Leeuwarden
