Bone Mass Changes in Anorexia Nervosa Patient Followed During 4 Years and Relationship Between Bone Loss and Adipokines.
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 180
- Locations
- 1
- Primary Endpoint
- Bone mineral density by Dual Energy X-ray Absorptiometry (DEXA)
Study Overview
Brief Summary
The mechanism of bone loss in anorexia nervosa is complex. Marrow adipose tissue seems to play a role in the regulation of bone metabolism. Adipocytes secrete cytokines and adipokines that either stimulate or inhibit adjacent osteoblasts. This study consist to explore the relationship in anorexia nervosa patients with change in bone mineral density and adipokines like leptin, adiponectin and Préf-1 Bone mineral densities will be measure in 180 anorexia nervosa patients at inclusion and every two years during 6 years.It is assessed blood and urinary calcium and phosphate levels, bone remodelling markers and adipokines (leptin, adiponectin and Préf-1)
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 35 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •anorexia patient defined by DSM IV diagnostic criteria
Exclusion Criteria
- •patient with other psychiatric disease
- •patient with other a metabolic bone disease
Outcomes
Primary Outcomes
Bone mineral density by Dual Energy X-ray Absorptiometry (DEXA)
Time Frame: 4 years
measured the evolution of the bone mineral density in 180 anorexia nervosa patients and the relationship with this change and adipokine
Secondary Outcomes
- Adiponectin plasma concentration by ELISA(at 2,4 and 6 years)
- Incidence of osteoporotic fractures(at 2,4 and 6 years)
- Interleukin-7 plasma concentration by ELISA(at 2,4 and 6 years)