Low Dose Ketamine Infusion for Postoperative Analgesia After Total Knee Arthroplasty: Optimum Dose to Reduce Morphine Consumption
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Pain
- Sponsor
- Mustafa Kemal University
- Enrollment
- 75
- Locations
- 1
- Primary Endpoint
- Optimal dose of Ketamine to reduce morphine consumption
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
This study evaluates continous infusion of low-dose ketamine during intraoperative and postoperative periods at three different doses to provide postoperative analgesia in total knee arthroplasty cases. Patients enrolled randomly into one of 2, 4, 6 μg / kg / min perioperative ketamine groups. All groups were given spinal anesthesia and intravenous patient controlled anesthesia. Ketamine was started when sensorial block reached T10 dermatome level before the skin incision. By the end of the operation, in all groups, ketamine infusions were reduced by half doses. Intravenous patient-controlled analgesia device was set to 2 mg bolus morphine with no basal infusion for 48 hours during the postoperative period.
Detailed Description
Multimodal analgesia, which involves the administration of two or more analgesic agents targeting different levels of pain pathways, is used to improve pain control while also to reduce opioid use and related side effects. Pain can be treated at various neurophysiological levels, including peripheral, spinal and cortical targets. One of the agents used in the multimodal analgesia technique is ketamine. Ketamine acts on the central nervous system (CNS) and has local anesthetic effect. Ketamine is an N-methyl D-Aspartate (NMDA) receptor antagonist, which appears to be the main mechanism of anesthetic and analgesic action at CNS and spinal cord receptors. Other mechanisms of action of ketamine include the interaction with opioid receptors, particularly mu and kappa receptors. Another effect is that it has local anesthetic effect in high doses. Studies have shown that ketamine is an effective agent in the treatment of postoperative pain. Continuous infusion of low-dose ketamine after total knee arthroplasty significantly reduced morphine consumption, and provided early rehabilitation without increasing side effects. However, when these studies are considered, there is no information about the optimal dose of ketamine that reduces opioid consumption at the highest level. In our study, continuous infusion of low-dose ketamine at different doses was planned to provide postoperative analgesia. Therefore, our first aim in this study was to find out the optimal dose that reduced morphine consumption for postoperative analgesia after TKA with continuous ketamine infusion at different doses. The secondary objectives are to evaluate early and late period pain, side effects, length of hospital stay, patient satisfaction, and recovery.
Investigators
Selim Turhanoglu
Professor Doctor
Mustafa Kemal University
Eligibility Criteria
Inclusion Criteria
- •ASA I-Ⅲ female patients scheduled for unilateral total knee arthroplasty
Exclusion Criteria
- •Patients younger than 18 years of age
- •ASA Ⅳ and above patients
- •Having previous knee surgery on the same side
- •Patients with allergies to drugs to be used in the study
- •Contraindication for spinal anesthesia
- •Body mass index 40 kg / m2 and above patients
- •Opioid tolerance
- •Patients with neurological or psychiatric disorders
- •Patients who do not have the ability to use patient controlled analgesia device
Outcomes
Primary Outcomes
Optimal dose of Ketamine to reduce morphine consumption
Time Frame: 48 hours from the operation
Ketamine infusions 2μg 4μg and 6μg / kg / min will be started preoperatively in group 1, 2 and 3 respectively when sensory block level reaches T10 after spinal anesthesia, and they will be reduced by half by the end of the operation. Ketamine infusion will be continued for 48 hours postoperatively.
Secondary Outcomes
- Early and late period pain(3 months from the operation)
- side effects,(3 months)
- length of hospital stay(3 months)
- patient satisfaction(3 months)