Optimization of polypharmacy in geriatric oncology

Not Applicable

Recruiting

Conditions: C15-C26
C50
C51-C58
C34
C43
C81-C96
C33
C61
C64
C67

Registration Number: DRKS00031024

Lead Sponsor: Deutsches Krebsforschungszentrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 514

Inclusion Criteria

• Diagnosis or recurrence requiring treatment of one of 22 frequent cancers (see chapter „Health condition for complete list) in last 5 years
• Exposure to polypharmacy, defined as = 5 chronically, concurrently used active substances
• At least 3 weeks of in-patient rehabilitation in a cooperating clinic are planned
• Sufficient capabilities for informed consent

Exclusion Criteria

• No written informed consent to participate
• No sufficient mental and physical capabilities to fill self-administered questionnaires.
• No sufficient knowledge of the German language.
• Missing information needed to conduct the medication review with the FORTA list
• No medication related problem at baseline (FORTA score = 0).
• Missing baseline information needed for the primary endpoint (global quality of life).

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in global quality of life (assessed by the European Organisation for Research and Treatment of Cancer’s Quality of Life Questionnaire’s Core 30 items (EORTC QLQ-C30) global health status (GHS)/quality of life score) from start of in-patient rehabilitation to 8-month follow-up

Secondary Outcome Measures

Name	Time	Method
• Medication quality (Total FORTA score and sub-scores for medication underuse, medication overuse and potentially inappropriate medication use)<br>• Global, domain-specific and symptom-related quality of life (All EORTC QLQ-C30 scores) <br>• Fatigue (Physical, emotional and cognitive fatigue as well as interference of fatigue with daily life (assessed with the EORTC Fatigue Questionnaire with 12 items (EORTC-FA12))<br>• Frailty (assessed by FRAIL-Scale) <br>• Dizziness (self-developed question)<br>• Falls (self-developed question)<br>• Hospitalizations (self-developed question)<br>• Cancer mortality (ICD-10 code C00-C97), non-cancer mortality and all-cause mortality (assessed by register matching for up to 10 years)