The role of the glutamatergic system in the extinction of conditioned reinforcement processes - The role of the glutamatergic system in the extinction of conditioned reinforcement processes

Central Institute of Mental Health0 个研究点开始时间: 2007年7月16日最近更新: 2012年5月29日

适应症

试验速览

暂无简介。

•Men and women between the age of 18 and 65 years; alcohol dependent according to DSM-IV criteria; controlled abstinent for 5-21 days after admission to inpatient detoxification (controlled with breathalyser), right-handed, able to speak the German language, able to accurately watch visual stimuli in the scanner environment (best corrected visual acuity < 0.8; Landolt C rings), and provide informed consent. Patients will be selected based on evidence of conditioned cue-related reactions at pre-treatment assessment using the alcohol-attentional bias measured with a dot-probe task.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Exclusion criteria include psychiatric Axis I and II disorders except abuse and dependence of alcohol and nicotine, seizure disorders, major diseases such as severe diabetes or liver cirrhosis; sensitivity to study medication (DCS) as evidenced by a history of adverse drug experience, pace maker or implanted metal that would prevent an MRI examination; positive drug screening (opioids, cannabinoids, benzodiazepines, barbiturates, cocaine, amphetamines), any current psychoactive medication, pregnancy, women with childbearing potential, and suicidal tendencies.

发起方