Role of doxycycline in treating different tissue lesions and thickening of lung and pleura: a pilot case based observation with different types of lesions.

Dr Parthasarathi Bhattacharyya1 个研究点分布在 1 个国家目标入组 30 人开始时间: 2008年9月7日最近更新: 2013年5月10日

试验速览

阶段: 不适用
状态: 已完成
发起方
入组人数: 30
试验地点: 1
主要终点: to see the long term doxycycline in different variety of lung lesions without overt symptoms and/or evidence of active co presence of infection/malignancy

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Tubercular pleuraleffusion can lead to pleural thickening that can result in permanentrestriction defect and even thoracic skeletal deformity. The initiation andmaintenance of such thickening possibly involves the participation of matrixmetalloproteinase, a class of enzyme that plays an integral role in thedevelopment of different tissue reactions to insults. Inhibition of matrixmetalloproteinases may help to prevent or treat pleural thickening.

研究设计

研究类型: Interventional
分配方式: Not Applicable
盲法: Not Applicable

入排标准

年龄范围: 15.00 Year(s) 至 75.00 Year(s)（—）
性别: All

入选标准

•Willing to give written informed consent
•Male/Female of age 15-75 years with lung and pleural lesion as described in protocol.

排除标准

•active infection or malignancy will be excluded.
•unable to meet the demand of the protocol for any reason.
•significant abnormality in liver and renal function
•features of chronic congestive cardiac failure (supported by echocardiography)
•history of exacerbation in past 1 month.

结局指标

主要结局

to see the long term doxycycline in different variety of lung lesions without overt symptoms and/or evidence of active co presence of infection/malignancy

时间窗: Nil

次要结局

未报告次要终点

研究者

发起方

Dr Parthasarathi Bhattacharyya

申办方类型

Other [[Non Govt Pulmonary Research Institute]]

研究点 (1)

Loading locations...

相似试验

已完成

不适用

Doxycycline cures non-infective-nonmalignant lung lessions.

CTRI/2013/10/004080Dr Parthasarathi Bhattacharyya30

已完成

2 期

Doxycycline in Human Pulmonary TuberculosisTuberculosis

NCT02774993National University Hospital, Singapore40

尚未招募

Phase 3 4

Comparing Treatments for Managing Lung Fluid in Cancer Patients

CTRI/2025/04/085011Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)45

招募中

2 期

Characterization of Tuberculosis Associated Lung Fibrosis and Respiratory Impairment, and Prevention Using DoxycyclineTuberculosis, Pulmonary

NCT06477185Makerere University200

已完成

不适用

The effects of doxycycline treatment on inflammation and endothelial function in advanced atherosclerosisatherosclerosis, peripheral arterial disease, inflammation, Doxycycline

NL-OMON23404none15