orepinephrine versus Epinephrine as the initial vasoactive agent in pediatric septic shock-A multicenter RCT

All India Institute of Medical Sciences0 个研究点目标入组 67 人开始时间: 待定最近更新: 2022年10月17日

试验速览

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•Children aged 2 months to 17 years with early septic shock, defined as children with suspect or confirmed sepsis and unresolved shock/hypoperfusion after the initial 20ml/kg fluid bolus.

•1.Children with fulminant myocarditis
•2.Children with unrepaired congenital heart disease
•3.Post-operative sepsis/septic shock within 72 hours of bypass surgery.
•4.Children with Severe Acute Malnutrition
•5.Children with chronic kidney disease.
•6.Parents not willing to participate in the study
•7.Caregiver/Physician unwilling for patient to be enrolled
•8.Post-arrest shock and cardiac dysfunction
•9.Moribund patients in whom anticipated survival < 24 hrs (since many are in are in recalcitrant downward spiral of overall condition where the impact of one or other vasoactive may be difficult to assess).

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