The Effect of Complex decongestıve Therapy on oxıdatıve Stress and antıoxıdants
- Conditions
- What Are the Effects of Lymphedema Treatment
- Interventions
- Other: Complex decongestive therapy
- Registration Number
- NCT06572098
- Lead Sponsor
- Baskent University
- Brief Summary
It is aimed to determine the changes of complex decongestive therapy applications on oxidative stress parameters and antioxidants in patients with lymphedema after breast cancer treatment.
- Detailed Description
Lymphedema, which is the most common late complication of patients receiving cancer treatment, affects the physical, social and psychological experiences of the individual and decreases the quality of life because it causes motor dysfunctions, cosmetic deformations and psychological disorders. The addition of radiotherapy to surgical intervention increases the risk of lymphedema by 36%.
When free radicals increase in intensity, they cause structural disorders in lipids, proteins and nucleic acids, and as a result, they are seen as a cause and risk factor for chronic diseases such as cancer, neurodegenerative diseases and cardiovascular diseases.
Due to their rapid metabolism and impaired cellular signaling mechanism, cancer cells have a high production of reactive oxygen species (ROS). High levels of ROS are generally harmful to cells and the redox state of cancer cells is different from that of normal cells. Cancer cells therefore maintain ROS levels at a moderately high tumorigenic level, above a low cytostatic level, but below levels that would be cytotoxic. The oxidative stress state in a cancerous cell is different from the oxidative stress state in a normal cell. It is also well known that increased oxidative stress and inflammation are associated with cancer risk. The number of studies investigating the effect of complex decongestive therapy, which is stated to be the most effective treatment method in the treatment of lymphedema, the most common complication after breast cancer treatment, on oxidative stress and antioxidant levels is quite limited.
In our study, we aimed to reveal the changes of complex decongestive therapy applications on oxidative stress parameters and antioxidants in patients with lymphedema after breast cancer treatment.
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- Female
- Target Recruitment
- 52
- treated for breast cancer developed lymphedema lymphedema with clinical stage Stage-2 and Stage-3 Female patients aged 25 years and older will be included.
- Treatment for lymphedema in the last three months ongoing metastatic disease those diagnosed with severe heart failure and/or arrhythmia infection in the affected extremities chemotherapy and patients taking drugs that have a toxic effect on the kidneys, those with liver disease.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description working group Complex decongestive therapy Patients will receive ten sessions of complex decongestive therapy. Patients will be evaluated for oxidative stress and antioxidant levels in three stages: before treatment, immediately after treatment and one month after the end of treatment.
- Primary Outcome Measures
Name Time Method PON1 will be assessed before treatment, immediately after treatment and one month after treatment. Paraoxonase
- Secondary Outcome Measures
Name Time Method OSİ will be assessed before treatment, immediately after treatment and one month after treatment. Oxidative Stress Index
Trial Locations
- Locations (1)
Baskent University
🇹🇷Adana, Çukurova, Turkey