The Validation and Development of Termination-of-Resuscitation (TOR) Rules in OHCA Patients in Asia Countries

Recruiting

• Conditions: Out-Of-Hospital Cardiac Arrest
• Interventions: Other: termination of resuscitation rules

• Registration Number: NCT05545176
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Objectives/Hypotheses

1. Prehospital termination-of-resuscitation (TOR) rules were developed in North American and European sites. Whether they remained valid in different geographic, ethnic, and cultural background areas is still under debate.

2. Differences in characteristics of out-of-hospital cardiac arrests (OHCAs) and configurations of emergency medical service (EMS) between the Western and Asian countries, including relatively lower rate of presenting shockable rhythm (i.e. ventricular fibrillation / ventricular tachycardia; VF/VT), lower rates of bystander CPR, less advanced life support (ALS) implementation, and less public access defibrillators, might create potential threats to the prediction accuracy of TOR rules.

3. We aim to conduct a study to validate the performance of ever published TOR rules in Asian OHCA population, including non-traumatic, traumatic, and pediatric OHCA patients. Furthermore, assess the possible variables that may impact the performance of TOR rules.

4. We also aim to develop new TOR rules based on PAROS registry for Asia population, focusing on non-traumatic, traumatic, and pediatric OHCA patients, respectively.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2007-01-01
• Status Verified: 2022-07
• Study First Submitted: 2022-09-14
• Study First Submitted QC: 2022-09-14
• Study First Posted: 2022-09-19
• Last Update Submitted: 2022-09-19
• Last Update Posted: 2022-09-22
• Primary Completion: 2032-06-01
• Study Completion: 2032-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 140000

Inclusion Criteria

• out of hospital cardiac arrest (OHCA) patients

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Exclusion Criteria

• age <18 years
• non-EMS transport to the emergency department
• obvious signs of death (e.g. decapitation, rigor mortis, lividity, and decapitation) or having do-not-resuscitate (DNR) orders
• missing data despite meeting the inclusion criteria.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
out of hospital cardiac arrest patients in Asia countries	termination of resuscitation rules	-

Primary Outcome Measures

Name	Time	Method
survival to hospital discharge	survival to 30-day hospitalisation	survival to 30-day hospitalisation

Secondary Outcome Measures

Name	Time	Method
Cerebral Performance Categories Scale (CPC)	CPC within 30-day hospitalisation	CPC Scale 1\~5, minimum value: 1; maximum value:5; lower score means greater outcome

Trial Locations

Locations (1)

National Taiwan University; 🇨🇳 Taipei, Taiwan