Pressure-Controlled Versus Volume-Controlled Ventilation in Low-Flow Anesthesia: A Randomized Controlled Trial on Intraoperative Respiratory Mechanics and Postoperative Pulmonary Function
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 40
- Locations
- 2
- Primary Endpoint
- Mean Ppeak (cmH₂O) at each time point; between-group difference.
Study Overview
Brief Summary
The aim of this observational study is to investigate the effects of ventilation modes on intraoperative and postoperative lung functions in patients under general anesthesia.
This study aimed to compare the effects of low-flow anesthesia on intraoperative respiratory mechanics and early postoperative pulmonary function between PCV and VCV in ASA I-II adult patients.
Detailed Description
Studies comparing the effects of pressure-controlled ventilation (PCV) and volume-controlled ventilation (VCV) on lung function under low-flow conditions are limited. In this study, the effects of PCV and VCV on intraoperative respiratory mechanics and early postoperative pulmonary function were investigated during low-flow anesthesia in ASA I-II adult patients undergoing routine anesthesia procedures.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •- age 18-65 years and American Society of Anesthesiologists (ASA) physical status I-II.
Exclusion Criteria
- •morbid obesity (BMI > 35 kg/m²),
- •scoliosis or thoracic deformity,
- •restrictive or obstructive lung disease,
- •prior thoracic or upper abdominal surgery,
- •history of major thoracic trauma or congenital chest wall anomaly,
- •active smoking or chronic use of corticosteroids,
- •β-agonists, bronchodilators, or antihistamines,
- •anticipated difficult airway
- •severe hypoxemia (SpO₂ < 90%) during induction.
Outcomes
Primary Outcomes
Mean Ppeak (cmH₂O) at each time point; between-group difference.
Time Frame: From post-intubation baseline until 30 minutes after initiation of low-flow anesthesia (approximately 45 minutes total).
Peak inspiratory pressure will be measured using the anesthesia workstation's built-in pressure monitoring system. Ppeak (cmH₂O) values will be automatically recorded at predefined time points: baseline after intubation, before low-flow transition, and 5, 10, 15, and 30 minutes after transition to low-flow anesthesia. Group comparisons will be reported as mean ± SD and analyzed for intergroup differences.
Secondary Outcomes
- Change in inspiratory score (number of balls raised).(Baseline to 30 minutes after initiation of low-flow anesthesia and Preoperative baseline and postoperative 1 hour)
Investigators
HULYA TOPCU, MD
Assoc. Prof. MD
Erol Olcok Corum Training and Research Hospital