Effect of fortification with powder nutrients in prevention and treatment of nutrient deficiency

Not Applicable

Recruiting

• Conditions: Deficiency Diseases; Iron deficiency anemia; Vitamin A Deficiency; Hearing loss; Anemia; C15.378.071; C18.654.521.500.133.628; C15.378.071.196.300; C18.654.521.500; C09.218.458.341

• Registration Number: RBR-4hm7mz
• Lead Sponsor: Faculdade de Nutrição da Universidade Federal de Goiás

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-07-23
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Children aged six to 48 months; anemic and non-anemic.

Exclusion Criteria

Children in treatment of anemia; malaria; HIV, hemoglobinopathies or hemochromatosis; low weight at birth; preterm birth (less than 37 weeks); twin; allergies reported to any components of the fortification sachet and/or to ferrous sulfate/folic acid.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome will be the difference in mean serum hemoglobin levels, <br>verified by electronic counting, between children receiving Nutrisus or supplementation with iron and folic acid, measured before and after the intervention.<br>

Secondary Outcome Measures

Name	Time	Method
Presence or absence of rs855791 polymorphism in the TMPRSS6 gene. Genotyping will be performed by real-time polymerase chain reaction (qPCR) using the inventoried assay (TaqMan® SNP Genotyping Assays, Waltham, Massachusetts, USA) for SNPs rs855791 located in the TMPRSS6 gene, which encodes a transmembrane serine protease 6. StepOne equipment will be used (Thermo Fisher Scientific, Massachusetts, USA).;Any change in serum vitamin A, verified by High Performance Liquid Chromatography (HPLC), measured before and after the intervention.;Any change in serum vitamin E, verified by High Performance Liquid Chromatography (HPLC), measured before and after the intervention.;Any change in serum vitamin D, <br>verified by amplified chemiluminescence, measured before and after the intervention.;Any change in serum folic acid level, verified by commercial fluoroimmunoassays, measured before and after the intervention.