The Effect of Frequency and Duration of Breaks in Sitting Time on Metabolic Cardiovascular Risk Factors
- Conditions
- Sedentary LifestyleOverweight and ObesityMetabolic Disease
- Interventions
- Behavioral: ProlongerBehavioral: IntermediateBehavioral: ControlBehavioral: Breaker
- Registration Number
- NCT02951624
- Lead Sponsor
- Rigshospitalet, Denmark
- Brief Summary
The primary aim of this study is to investigate the acute effect of the frequency and duration of breaks in sitting time on the metabolic risk factor profile.
- Detailed Description
Fifteen (n=15) sedentary adult overweight males will be included in the study. All participants will undergo the four interventions in a randomized cross-over design. Wash out between intervention will be minimum four days.
Control (CON): Participants will be sedentary. Sedentary time will be spent sitting in a chair, restricted to sedentary behaviors (working on a computer, reading, watching TV, etc.), with a target MET below 1.5 (i.e. 1.5 times REE). Participants will only be allowed to stand or walk to go to the toilet.
Breaker: Participants will be breaking up prolonged sitting with 2 min intervals of low intensity walking.
Intermediate: Participants will be breaking up prolonged sitting with 6 min intervals of low intensity walking
Prolonger: Participants will be breaking up prolonged sitting with 12 min intervals of low intensity walking
All interventions will be matched for total physical activity as well as sitting. Thus, we aim for the active interventions to be iso-caloric.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 14
- Males, age 20-50 years, waist-to-height ratio ≥ 0.5 and/or waist circumference ≥ 102 cm.
- Clinically diagnosed diabetes, uncontrolled hypertension, use of glucose- and/or lipid-lowering medication, smoking, evidence of thyroid, liver, lung, heart or kidney disease, non-sedentary occupation, and VO2max levels above the considered average fitness according to age (Shvartz & Reibold 1990), contraindications to increased levels of physical activity.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Prolonger Prolonger Total duration of sedentary time and LPA time will be the same as in Breaker. Sedentary time will be done in bouts of 108 min with 12 min of LPA between each bout. Intermediate Intermediate Total duration of sedentary time and LPA time will be the same as in Breaker. Sedentary time will be done in bouts of 54 min with 6 min of LPA between each bout. Control Control Participants will spend 8 hours sedentary. Sedentary time will be spent sitting in a chair, restricted to sedentary behaviors (working on a computer, reading, watching TV, etc.) Participants will only be allowed to stand or walk to go to the toilet. Breaker Breaker Participants will spend a total of 7 hours and 12 min sedentary and a total of 48 min breaking sitting time with LPA. Sedentary time will be done in bouts of 18 min with 2 min of light walking.
- Primary Outcome Measures
Name Time Method AUC post prandial glucose concentration 6 hours
- Secondary Outcome Measures
Name Time Method AUC post prandial hdl concentration 6 hours Mean 24 hour glucose concentration 24 hours AUC post prandial glucagon concentration 6 hours AUC post prandial insulin concentration 6 hours AUC post prandial c-peptide concentration 6 hours Variation in 24 hour glucose concentration 24 hours AUC post prandial triglyceride concentration 6 hours AUC post prandial ldl concentration 6 hours Maximum in 24 hour glucose concentration 24 hours AUC post prandial total cholesterol concentration 6 hours
Trial Locations
- Locations (1)
Center for Physical Activity Research, Copenhagen University Hospital
🇩🇰Copenhagen, Denmark