Prevention of POstoperative Nausea and Vomiting with metoclopramide and dexamethasone

niversity of Leipzig (Germany)0 个研究点目标入组 3,000 人开始时间: 2005年10月17日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Age greater than 18 years
•2. Patient receives balanced anaesthesia (with intubation) or spinal, peridural, or combined spinal epidural anaesthesia for any of the following surgeries:
•2.1. Hysterectomy
•2.2. Cholecystectomy
•2.3. Hernia repair
•2.4. Otorhinolaryngological surgery
•2.5. Thyroid surgery
•2.6. Total endoprothesis of the hip or knee
•2.7. Arthroscopy
•3. Patient is able to answer questions regarding symptoms (taking his/her physical, emotional and mental constitution, understanding and compliance into consideration)
•4. Informed consent in writing

•1. Anaesthesiological risk level of American Society of Anaesthesiologists (ASA) IV
•2. Presence of at least one of the following cardiac risk factors:
•2.1. Unstable angina pectoris
•2.2. Heart failure with New York Heart Association (NYHA) greater than or equal to III and/or left ventricular ejection fraction (LVEF) less than 40%
•2.3. Atrioventricular block grade II or III
•3. Current treatment with any of the following:
•3.1. Study medication
•3.2. Other anti-emetic drugs except ranitidine
•3.3. Selective serotonin reuptake inhibitors (SSRIs)
•3.4. Monoamine oxidase (MAO) inhibitors
•3.5. Tricyclic antidepressants
•3.6. Antiarrhythmics class I or III
•4. Disposition of the patient to malignant hyperthermia, or known occurrence thereof
•5. History of any of the following diseases:
•5.1. Parkinson's disease and other extrapyramidal-motoric impairment
•5.2. Hepatic insufficiency (alanine aminotransferase [ALT] and/or aspartate aminotransferase [AST] greater than 2 x upper normal value [UNV])
•5.3. Renal insufficiency (Creatinine greater than 2 x UNV)
•5.4. Phaeochromocytoma
•5.5. Mechanical ileus
•5.6. Epilepsy
•6. Known anaphylaxis following any of the study drugs
•7. Pregnancy or breast feeding
•8. Participation in another therapeutic trial
•9. Planned or foreseeable post-operative application of propofol
•10. Planned or foreseeable post-operative artificial respiration
•11. Planned or foreseeable leaving of a stomach tube post-operatively

发起方

niversity of Leipzig (Germany)