management of patients who do not respond to initial anti-tuberculosis treatment
Phase 3
- Conditions
- Health Condition 1: null- Multidrug Resistant Tuberculosis
- Registration Number
- CTRI/2014/01/004294
- Lead Sponsor
- nited State Agency for International Development
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Other (Terminated)
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
A patient whose TB is due to bacilli resistant to at least isoniazid and rifampicin with or without resistance to other drugs will be eligible for the study.
At least one sputum smear examined within 10 days of starting treatment should be positive for AFB.
Exclusion Criteria
Patients under 15 years of age
Pregnant women
Having a current major psychiatric illness
Having had over one month treatment with any second line anti-TB drugs.
HIV positive cases
A patient with concurrent illness such as epilepsy, renal or hepatic problems.
Too sick for ambulatory treatment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method sputum smear and culture conversion at 3 months and 6 months of treatmentTimepoint: sputum smear and culture conversion at 3 months and 6 months of treatment
- Secondary Outcome Measures
Name Time Method Favourable bacteriological response at the end of treatment. <br/ ><br>Adverse reactions to anti-TB drugs <br/ ><br>Timepoint: at 24 months of treatment