Effects of Combined Grape Seed Extract and L-citrulline Supplementation on Hemodynamic Responses in Young Males
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- Systolic blood pressure (mmHg)
研究概览
简要总结
This study was to examine the additive benefits with combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study.
详细描述
The investigators aimed the additive effects of combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study. Effects of 7 days of combined GSE with L-citrulline supplementation on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), cardiac output (CO), total vascular conductance (TVC), and oxygen consumption (O2) were examined at rest and during cycling exercise.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy males
排除标准
- •cardiovascular and/or pulmonary disease, musculoskeletal disorders, or medications that prevent the safe completion of the exercise protocol
研究组 & 干预措施
Randomized double blind placebo design
Placebo
干预措施: Grape seed extract (Dietary Supplement)
Randomized double blind placebo design
Placebo
干预措施: Placebo (Dietary Supplement)
Randomized double blind grape seed extract design
Grape see extract
干预措施: Placebo (Dietary Supplement)
Randomized double blind grape seed extract design
Grape see extract
干预措施: Grape seed extract (Dietary Supplement)
结局指标
主要结局
Systolic blood pressure (mmHg)
时间窗: 7 days
by sphygmomanometer
Diastolic blood pressure (mmHg)
时间窗: 7 days
by sphygmomanometer
Stroke volume (ml)
时间窗: 7 days
measured using Physio Flow (non-invasive device)
Cardiac output (l/min)
时间窗: 7 days
calculated: HR (bpm) x SV (ml)
Total vascular conductance (ml/min/mmHg)
时间窗: 7 days
calculated: CO (ml/min) / MAP (mmHg)
Mean arterial pressure (mmHg)
时间窗: 7 days
calculated (MAP = (SBP-DBP)/3 + DBP
Heart rate (bpm)
时间窗: 7 days
measured using Physio Flow (non-invasive device)
次要结局
未报告次要终点