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临床试验/NCT04048291
NCT04048291已完成不适用

Efficacy of Brisk Walking on Improving Balance and Gait Performance, and Functional Mobility in Parkinson's Disease - a Randomized Controlled Trial

The Hong Kong Polytechnic University2 个研究点 分布在 1 个国家目标入组 80 人开始时间: 2018年10月15日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
80
试验地点
2
主要终点
Mini-Balance Evaluation Systems Test (miniBest) total scores

研究概览

简要总结

Parkinson's disease (PD) is the second most common neuro-degenerative disease in older people. Falls are common among people PD with the incidence rate up to 70% and have strong associations with the severity of the disease, balance impairment, and freezing of gait.The abnormal gait characteristics include reduction in stride length, gait speed and arm swing, and increase in cadence. Gait training, balance training, aerobic training, Tai chi and dance training are common types of physical rehabilitation for PD. Brisk walking is a way of walking with a pace faster than normal, and it can improve dynamic balance for senior men and balance function for chronic stroke clients.

Brisk walking also promotes cardiopulmonary fitness and walking endurance in elderly women, healthy middle-age and older adults, active elderly men and chronic stroke clients. Our previous pilot randomized controlled trial on the effects of a 6-week home-based brisk walking program indicates that it is feasible and safe for the early PD population with improved walking capacity measured by 6-minute walk distance. The positive effects could carry over to 6 weeks after treatment completion. Up-to-date, the short- and long-term effects of brisk walking in improving balance and gait performance, and functional capacity in people with PD have not yet been well investigated. In order to promote their balance and functional capacity in longer term, more sustained training and better exercise adherence may be necessary.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Double (Investigator, Outcomes Assessor)

入排标准

年龄范围
30 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Parkinson disease diagnosed by neurologist with Hoehn & Yahr stage 2 or 3
  • Having a 30-meter walking ability

排除标准

  • Significant neurological condition (other than Parkinson's disease)
  • Musculoskeletal conditions affecting gait, balance or upper limb functions
  • Had received deep brain stimulation surgery
  • Cognitive impairment with Montreal Cognitive Assessment score <24
  • Present with on-off motor fluctuations.

结局指标

主要结局

Mini-Balance Evaluation Systems Test (miniBest) total scores

时间窗: 1 year

To evaluate dynamic balance in four domains: anticipatory postural adjustments, postural reactions, sensory integration and gait stability. The miniBEST scores range from 0 to 28, with a higher score indicates better dynamic balance.

Six-minute walking test (6MWT) distance

时间窗: 1 year

The maximum walking distance covered during a validated six-minute walk test (6MWT) to document participants' aerobic endurance level and walking capacity

Movement Disorder Society Unified Parkinson Disease Rating Scale Part III (MDS-UPDRS-III) score

时间窗: 1 year

This score consists of 18 items in 33 questions examining the motor and functional capacity of people with Parkinson's disease by the assessor. Each question will be rated from 0 (normal) to 4 (severe). The MDS-UPDRS-III score ranges from 0 to 132, with higher scores indicating more severe motor and functional impairments

次要结局

  • Dual-task timed-up-and-go-time(1 year)
  • Parkinson Disease Questionnaire-39 (PDQ-39) summary index score(1 year)
  • Injurious fall rate(1 year)
  • Injurious fall risk(1 year)
  • Fast gait speed(1 year)
  • Fall risk(1 year)
  • Fall rate(1 year)
  • Movement Disorder Society Unified Parkinson Disease Rating Scale Part I (MDS-UPDRS-I) score(1 year)
  • Activities-specific Balance Confidence (ABC) Scale score(1 year)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Margaret Kit Yi Mak

Professor

The Hong Kong Polytechnic University

研究点 (2)

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