Optical coherence tomography (OTC) in the follow-up of patients with X-linked adrenoleukodystrophy (X-ALD) and Zellweger spectrum disorders (ZSD).

Recruiting

• Conditions: Schilder's disease; X-ALD; X-linked adrenoleukodystrophy; 10029299

• Registration Number: NL-OMON44231
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 230

Inclusion Criteria

Patients:
1. Established diagnosis of X-ALD or ZSD (either biochemically and/or genetically).
2. Must be able to undergo ophthalmological examination and optical coherence tomography, i.e. must be able to follow instructions and not move for several minutes.;Subjects eligible to participate as healthy controls must meet all of the following criteria:
1. Willing to visit the hospital*
2. 12 years or older
3. Informed consent obtained from participant*
4. Informed consent obtained from participant or legal guardian in case of a minor

Exclusion Criteria

Patient or control:
1. Pre-existing eye disease that creates confounders in interpretation of OCT measurements
2. Unable to follow instructions, which makes ophtalmological examination and OCT impossible (e.g. age or mental retardation)

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>OCT parameters (i.e. RNFL, GCL en IPL).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Neurologic examination, SF-36, EDSS, ALDS.</p><br>