Optimization of the antidepressant effect of electroshock

Completed

• Conditions: Major depression; nortriptyline; ECT; combination treatment; tricyclic antidepressantsDutch keywords: Depressieve stoornis; combinatie behandeling; tricyclische antidepressiva

• Registration Number: NL-OMON20033
• Lead Sponsor: Erasmus MC Rotterdam

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

•Diagnosis Major depression according to DSM-IV-TR, established with depression part of the SADS

•Baseline HAM-D score ≥ 18

Exclusion Criteria

•Alcohol or drugdependecy during the last 3 months.

•Severe neurological disorders.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean change in HAM-D score<br /><br>Proportion of responders (&#8805; 50% reduction of HAM-D score)<br /><br>Proportion of remitters (final HAM-D score 7 or lower)

Secondary Outcome Measures

Name	Time	Method
Speed of response defined as the number of ECT sessions required for remission.