Monitoring Living Donor Liver Functions by Thromboelastometry

Completed

• Conditions: THROMBELASTOGRAPHY and Liver Graft Functions
• Interventions: Procedure: living donor liver transplantation

• Registration Number: NCT02336191
• Lead Sponsor: Mansoura University

Brief Summary

A prospective Observational study including 50 living donor liver transplant recipients to monitor the graft functions through thromboelastometry

Detailed Description

This is a prospective observational study Includes 50 living donor liver transplant recipients performed in gastroenterology surgical center - Mansoura University liver transplantation program.

Study period: from June 2014 to May 2015 The early post-operative graft functions will be correlated with concomitant monitored thromboelastometric (TEM) parameters derived from a ROTEM Delt device

TEM Samples will be collected at the following times:

Pre-transplant 10 minutes post portal declamping at ICU admission Morning of Days from 1 to 7 Laboratory data relevant to graft functional status will be collected at the same times.

Study Timeline

• Study Start: 2014-06
• Study First Submitted: 2015-01-03
• Study First Submitted QC: 2015-01-07
• Study First Posted: 2015-01-12
• Primary Completion: 2015-04
• Status Verified: 2015-08
• Study Completion: 2015-08
• Last Update Submitted: 2017-03-24
• Last Update Posted: 2017-03-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Living donor liver transplant recipients successively performed in the liver transplantation program - Mansoura university

Exclusion Criteria

• Non

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
LDLT Recipients	living donor liver transplantation	Patients subjected to living donor liver transplantation

Primary Outcome Measures

Name	Time	Method
r (correlation coefficient) between clot firmness time at 20 minutes, clotting time and INR	20 minutes after starting the TEG test	Both blood sample for INR and other lab test and the sample for TEG will be simultaneously drawn from the arterial line for reading of days 0,1 and 2 then from the CVP for the rest of the study readings

Secondary Outcome Measures

Name	Time	Method
r (correlation coefficient) between clotting time , clot firmness time at 20 minutes and serum bilirubin	20 minutes after the start of the TEG test
r (correlation coefficient) between clotting time , clot firmness time at 20 minutes and serum SGPT	20 minutes after the start of the TEG test

Trial Locations

Locations (1)

Gastroenerology Surgical Center - Liver transplantation program; 🇪🇬 Mansoura, Dakahlia, Egypt