Extended Platelet Parameters as a Means to Differentiate Immune Thrombocytopenia From Hypo-proliferative Thrombocytopenias.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Increased platelet density
研究概览
简要总结
To utilise extended platelet parameters in order to individuate Immune Thrombocytopenia (ITP) from hypo-proliferative causes of thrombocytopenia.
To develop the clinical potential of the extended platelet parameters as they pertain to distinguishing different causes of thrombocytopenia from one another.
To test the hypothesis that mean platelet component (MPC) and mean platelet mass (MPM) might distinguish between thrombocytopenia related to bone marrow dysfunction and immune mediated destruction of platelets.
详细描述
Patient to be registered at the Haematology-Oncology department Mount Sinai Roosevelt Hospital.
Inclusion criteria are as follows:
All individuals age 18yrs and above capable of rendering consent Known ITP confirmed by response to IVIG, glucocorticoids, or WinRho and exclusion of all other possible causes of thrombocytopenia Confirmed aplastic anemia [as assessed through bone marrow trephine biopsy]. Chemotherapy-induced thrombocytopenia assessed at time of predicted nadir.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All individuals age 18yrs and above capable of rendering consent
- •Known ITP confirmed by response to intravenous immune globulin (IVIG), glucocorticoids, or winRho and exclusion of all other possible causes of thrombocytopenia
- •Confirmed aplastic anemia [as assessed through bone marrow trephine biopsy]
- •Chemotherapy induced thrombocytopenia assessed at time of predicted nadir.
排除标准
- •Suspected multifactorial thrombocytopenias and thrombocytopenia due to hypersplenism
- •Chronic active hepatitis
- •Those infected with HIV
- •Patients receiving concomitant radiotherapy
- •Gravid females
- •Congenital thrombocytopenias
结局指标
主要结局
Increased platelet density
时间窗: 12 months
次要结局
- mean platelet mass(12 months)