Fluid and Nutrition in Elective Hip Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in Insulin Sensitivity (Percent)
研究概览
简要总结
The purpose of this study is to determine whether fluid or glucose administration before hip replacement surgery minimizes postoperative muscle breakdown (catabolism), fatigue and disturbances in carbohydrate metabolism.
详细描述
- How can a simple and safe way to measure the body's tendency to transient diabetes associated with surgery?
- Can fluid or glucose administration before elective hip surgery, minimizing post-operative muscle breakdown (catabolism), fatigue and disturbances in carbohydrate metabolism?
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient scheduled for hip surgery.
排除标准
- •Endocrinological disorders.
研究组 & 干预措施
Fasting
patients undergo surgery in the fasting state
干预措施: Fasting. (Behavioral)
Water administration
Patients undergo hip surgery after receiving 800 ml water by mouth the morning 2 hours before surgery
干预措施: Water administration (Dietary Supplement)
carbohydrate drink
Patients undergo hip surgery after receiving 800 ml carbohydrate drink by mouth
干预措施: carbohydrate drink (Dietary Supplement)
结局指标
主要结局
Change in Insulin Sensitivity (Percent)
时间窗: Day before surgery (approximately 3 PM) and in the morning after surgery (approx. 7.30 AM).
Insulin sensitivity (micro-mol per kg per minute glucose uptake) was calculated based on an intravenous glucose tolerance test (Theor Biol Med Model 2011, 8: 12) on the day before surgery. The percent change was taken as (day after - day before) / day before
次要结局
- Muscle Catabolism(From the morning after surgery (07.30) up to the morning two days after sthe surgery (07.30))
研究者
Robert Hahn
Research Director
Sodertalje Hospital