PRP Use in Treatment of Fistula Ano

Not Applicable

Active, not recruiting

• Conditions: Fistula in Ano
• Interventions: Other: platelet rich plasma

• Registration Number: NCT04187651
• Lead Sponsor: Uşak University

Brief Summary

In treatment of perianal fistula several methods are described. However, since the Hippocrates basics of surgical treatment has not changed very much. the aim of this study is to evaluate the effectiveness of PRP gel in treatment of perianal fistula.

Detailed Description

Perianal fistula is a chronic condition that seriously affects the patients' quality of life. There are different treatment modalities used in treatment. Recently sphincter preserving methods are becoming more popular with low complication rates. Most of this methods aiming the closure of fistula tract by different pathways.

Platelet rich plasma (PRP) is used in a wide range of conditions in medicine. The investigator's team showed the effective treatment of pilonidal disease by use of PRP gel. In the recent study, aim to evaluate the effectiveness of PRP gel in treatment of perianal fistula.

Patients with perianal fistula will be evaluated for the study. After taking permission with informed consent; cases will be included in the study. Cases with inflammatory bowel disease, platelet function disorders or connective tissue disorders that may alter wound healing will be excluded from the study.

After, PRP application to the fistula tract patients will be taken to follow up. Perianal fistulas will be followed by magnetic resonance imaging 1 month after the application. Pre-application and post-application scans will be used for the evaluation of the treatment success.

Study Timeline

• Study Start: 2019-11-20
• Study First Submitted: 2019-12-02
• Study First Submitted QC: 2019-12-04
• Study First Posted: 2019-12-05
• Status Verified: 2025-01
• Primary Completion: 2025-01-01
• Last Update Submitted: 2025-01-28
• Last Update Posted: 2025-01-29
• Study Completion: 2025-12-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• patients with perianal fistula
• signing the informed consent form
• above the age of 18

Exclusion Criteria

• inflammatory bowel disease
• previous radiation therapy
• having connective tissue disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
PRP gel application	platelet rich plasma	PRP application for perianal fistula

Primary Outcome Measures

Name	Time	Method
percentage of the cure rate	1 month	closure of the fistula tract will be evaluated by physical examination and magnetic resonance imaging

Trial Locations

Locations (1)

Uşak University; 🇹🇷 Uşak, Turkey