nbiased DECONvolution of obesity

Not Applicable

• Conditions: E66; Obesity

• Registration Number: DRKS00015814
• Lead Sponsor: niversitätsklinikum FreiburgKlinik für Allgemein- und Viszeralchirurgie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-09
• Study Completion: 2020-12-17
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

1) Obesity WHO III (BMI>40 kg/m2)
2) Obesity WHO II (BMI 35-40 kg/m2) + obesity related diseases (diabetes, hypertension, hyperlipidemia, osteoarthrosis, obstructive sleep apnea, obesity hypoventilation syndrome, nonalcoholic fatty liver disease (NAFLD) and/or nonalcoholic steatohepatitis (NASH), pseudotumor cerebri, gastroesophageal reflux disease, asthma, venous stasis disease, severe urinary incontinence, debilitating arthritis, impaired quality of life, disqualification for other surgeries as a result of obesity (i.e., surgeries for osteoarthritic disease, ventral hernias, or stress incontinence)
Female, caucasian, >=18 years <50 years

Exclusion Criteria

Patients with high perioperative risk, previous bariatric surgery, carcinoma within the last 5 years,
severe psychiatric disease, drug or alcohol abuse,

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
This study has no comparative outcome. The focus lies in its bioinformatic approach which relies on dimensional reduction and clustering of RNAseq-data and quantifiable clinical parameters to define patient clusters. In this way the entire spectrum currently globally termed as obesity will be more precisely defined.

Secondary Outcome Measures

Name	Time	Method
see primary outcome