Mechanism of Thrombocytopenia in Small for Gestational Age Infants Versus Infants With Maternal Preeclampsia Exposure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- To determine the mechanism of thrombocytopenia in small for gestational age infants versus infants with maternal preeclampsia exposure
研究概览
简要总结
This research project is studying the causes for low platelet levels in preterm infants. Platelets are a component of blood that helps with clotting. The purpose of this study is to determine whether the cause for low platelet levels is the same in infants who are born to mothers with preeclampsia and infants who are small for gestational age.
详细描述
Thrombocytopenia is a common entity in infants who are born to mothers with preeclampsia and in infants who are small for gestational age. There have been several theories to the mechanism underlying thrombocytopenia in these groups of patients. One mechanism suggests that thrombocytopenia in these populations may be secondary to underproduction of platelets. Other studies have implied that low platelet levels may be due to endothelial activation causing platelet consumption. This study is being performed to help determine the mechanism causing thrombocytopenia in infants born to mothers with preeclampsia and comparing it to the mechanism of thrombocytopenia in infants who are small for gestational age.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Infants who are less than 34 weeks gestation
- •Infants born to mothers with preeclampsia
- •Infants who are born small for gestational age whose mother did not have preeclampsia
排除标准
- •Infants who are greater than 34 weeks gestation
- •Infants with known congenital anomalies or known congenital infections
结局指标
主要结局
To determine the mechanism of thrombocytopenia in small for gestational age infants versus infants with maternal preeclampsia exposure
时间窗: Each infant will only be enrolled during the time of birth until cord blood is collected.
次要结局
未报告次要终点