NCT01229917已完成4 期
Rhinovirus Study With Lactobacillus Rhamnosus GG
Valio Ltd1 个研究点 分布在 1 个国家开始时间: 2010年10月28日最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 试验地点
- 1
研究概览
简要总结
The purpose of this study is to evaluate the symptom impact of probiotic Lactobacillus rhamnosus GG during rhinovirus infection.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female in general good health (stabilized chronic illnesses and regular medications are accepted, if not otherwise mentioned in the
排除标准
- •Age 18-65 years
- •Serum neutralizing antibody titer of 1:4 or less for the challenge rhinovirus
- •No clinically significant finding on the pre-study nasal examination
- •Females must have a negative urine pregnancy test, and women of child-bearing potential must be using an effective method of birth control such as, but not limited to birth control pills, contraceptive foam, diaphragm, IUD, surgical sterilization, abstinence, or condoms
- •Written informed consent must be obtained at enrollment into the study
- •Exclusion Criteria:
- •Suffer from or have a history of significant allergic rhinitis at the time of study
- •Bronchial asthma or other lower respiratory tract diseases, such as chronic obstructive lung disease or emphysema
- •Nasal abnormalities or other nasal pathology, such as irreversible nasal mucosal hypertrophy or severe nasal septum derivation
- •Pregnancy or lactation
- •History of alcohol abuse (regularly consumes 5 or more alcohol drinks per day) and/or drug abuse during the 12 month period immediately preceding study enrollment
- •Daily smoking within the past 2 years
- •Use of investigational product or participation in a device trial during the 30 day period immediately preceding study enrollment
- •Previous participation in an experimental study with rhinovirus 39
- •Allergy to any ingredient in the study product
- •Have, as determined by the investigator and/or the sponsor's medical monitor, any surgical or medical condition or take any medication or dietary supplement that could interfere with the interpretation of study results or jeopardize the safety of the subject
研究者
研究点 (1)
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