Effect of Hydrocortisone on Improving Outcome of Pneumatic Reduction of Infantile Intussusception

Not Applicable

Recruiting

• Conditions: Intussusception
• Interventions: Drug: Saline; Drug: Hydrocortisone

• Registration Number: NCT02691858
• Lead Sponsor: Cairo University

Brief Summary

Intussusception is one of the most frequent causes of acute bowel and second most common cause of acute abdominal pain in pediatric age .95 % of cases are idiopathic, the rest are either due to pathological lead point or post operative. Treatment of intussusception must start with medical resuscitation, then radiological or operative reduction of intussusception.

Our surgery team has used hydrocortisone with the medical resuscitation to improve the success rate of pneumatic reduction and decrease the number of reduction trials.

Detailed Description

Experimental group will be given single dose IV Hydrocortisone 10 mg/kg with Resuscitation before attempting first trial of pneumatic reduction and the outcome measured.

Control group will be given Saline 100 ml IV single injection with Resuscitation before attempting first trial of pneumatic reduction and the outcome measured.

Study Timeline

• Study Start: 2015-04
• Study First Submitted: 2016-02-22
• Study First Submitted QC: 2016-02-22
• Study First Posted: 2016-02-25
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-25
• Last Update Posted: 2024-08-27
• Primary Completion: 2025-06
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Infantile Intussusception

Exclusion Criteria

• Peritonitis Pneumoperitoneum Morbid patients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Saline	Saline	Saline IV 100 ml with Resuscitation before attempting reduction, single dose with Resuscitation before attempting reduction
Hydrocortisone	Hydrocortisone	Hydrocortisone IV 10 mg/kg with Resuscitation before attempting reduction, single dose with Resuscitation before attempting reduction

Primary Outcome Measures

Name	Time	Method
Success of Pneumatic Reduction	1 Hour	Comparing number of Successful Pneumatic Reductions in both groups

Secondary Outcome Measures

Name	Time	Method
Reducing number of trials of Pneumatic Reduction	2 Hours	Comparing average number of Pneumatic Reduction trials between both groups
Reducing complications	2 Hours	Comparing number of complications in both groups

Trial Locations

Locations (1)

Cairo University Pediatric Hospital; 🇪🇬 Cairo, Egypt