NCT00628082Unknown不适用
Energetic Abnormalities in Heart Failure With Preserved Ejection Fraction
University Hospital Birmingham1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2006年3月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Complete echocardiographic assessment to assess resting diastolic function
研究概览
简要总结
Up to half of all patients with heart failure are found to have normal pumping function of the heart muscle, but show abnormalities in the way the heart muscle relaxes and fills with blood. These patients often have high blood pressure, and tend to have stiff arteries and stiff heart muscle. We wish to test the hypothesis that these patients have abnormal energy stores in their heart muscle.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
入排标准
- 年龄范围
- 40 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical features consistent with heart failure
- •LVEF ≥ 50%, with no evidence of significant valvular disease, no hypertrophic cardiomyopathy, and no evidence of pericardial constriction
- •A peak VO2 < 80% predicted, with a pattern of gas exchange on metabolic exercise testing indicating a cardiac cause for limitation
排除标准
- •Objective evidence of lung disease on formal lung function testing
- •Reversible myocardial ischaemia on contrast-enhanced myocardial stress
- •Echocardiography, and evidence of exercise-induced mitral regurgitation
- •Obesity (BMI >35) or a locomotor cause for exercise limitation
结局指标
主要结局
Complete echocardiographic assessment to assess resting diastolic function
时间窗: 1 DAY
Assessment of resting large artery function
时间窗: 1 DAY
Multiple Gated Acquisition Scan
时间窗: 1 DAY
Cardiac Magnetic Resonance Spectroscopy
时间窗: 1 DAY
Metabolic Exercise Testing (VO2max)
时间窗: 1 DAY
次要结局
未报告次要终点
研究者
研究点 (1)
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